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Activity 3: Characterization and Simulation: Cell Environment

Activity 3: Characterization and Simulation: Cell Environment. Peter M. Anderson, Materials Science Heather Powell, Materials Science/Biomedical Engineering Samir Ghadialli, Biomedical Engineering Gregory Lafyatis, Physics Supported Graduate Student: Yanyi Xu

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Activity 3: Characterization and Simulation: Cell Environment

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  1. Activity 3: Characterization and Simulation:Cell Environment Peter M. Anderson, Materials Science Heather Powell, Materials Science/Biomedical Engineering Samir Ghadialli, Biomedical Engineering Gregory Lafyatis, Physics Supported Graduate Student: Yanyi Xu Support: OSU Materials Research Institute

  2. Activity 3: Goal • Quantify • the 3D mechanical environment experienced by cells • Approach • accurately characterize fibrous matrix geometry • inform finite element models with • fiber properties • matrix geometry • matrix macromechanical response • use FE model to determine • local mechanical environment (Green's function) • cell force footprints • correlate environment and differentiation cyclic excitation

  3. Activity 3: FE Simulations • Relates Structure and Properties mechanical properties: fibers matrix geometry Agarwal (AFMic) Powell/Ghadiali (OM)Lafyatis (DeCo) Ghadiali (SiWa) Finite Element Model mechanical response: matrix cell force footprint Powell (UniT) Anderson (NInd) energy partitioning

  4. Activity 3: Matrix Geometry • Confocal Fluorescence Microscopy • heavy die loading/imaging (Powell/Ghadiali) • deconvolution (Lafyatis) • conversion to finite element data file (Ghadiali/Anderson)

  5. Activity 3: Preliminary Simulations • ABAQUS software • 54 fibers: beam elements • 20 x 20 x 5 mm system • 110% axial strain • imposed in X direction. • Negative transverse strain • Possion effect Simu Scaffold Simulations LE fibers Ef = 1.11MPa Expe riments HyperE fibers LE FibersEf = 0.35MPa Z Y X

  6. Activity 3: Preliminary Simulations

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