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Ribosome profiling

Ribosome profiling

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Ribosome profiling

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  1. Ribosome profiling Underscoring the value of measuring gene expression at the level of translation has led to the development of ribosome- profiling techniques. Ribosome profiling is a direct method for determining the precise mRNA region being read by the ribosome, to examine the transcripts associated with the translation machinery directly. Ribosome profiling providing a cellular snapshot of protein production, with the potential to inform nearly every domain of biological and clinical research. Compared with traditional RNA-Seq experiments, ribosome profiling is designed specifically to measure mRNA involved inactive translation. Ribosome profiling strategy that is based on the deep sequencing of ribosome-protected mRNA fragments and enables genome- wide investigation of translation with sub cordon resolution. Using nuclease digestion, the ribosome position and the translated message can be precisely determined by analyzing the protected ~30-nt area of the mRNA template. Fig.1 Ribosome-protected mRNA Learn more about ribosome profiling at: https://www.cd-genomics.com/ribosome-profiling.html

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