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European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership

European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership. 19 July 2011 IAS 2011 Rome, Italy Charles S Mgone EDCTP Executive Director. About EDCTP.

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European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership

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  1. European HIV/AIDS programmes: EDCTP as a model of Europe-Africa partnership 19 July 2011 IAS 2011 Rome, Italy Charles S Mgone EDCTP Executive Director

  2. About EDCTP • Partnership between European member states, European Commission and Africa in collaboration with like minded organisations in fighting diseases of poverty – HIV/AIDS, malaria and tuberculosis • This is realised by funding clinical trials and research capacity to accelerate development of intervention tools including drugs, vaccines, microbicides and diagnostics against these diseases

  3. The partnership EDCTP-EEIG member states • Austria • Belgium • Denmark • France • Germany • Greece • Ireland • Italy • Luxembourg • Netherlands • Norway • Portugal • Spain • Sweden • Switzerland • United Kingdom Sub-Saharan African countries • Benin • Botswana • Burkina Faso • Cameroon • Congo • Cote d’Ivoire • Democratic Republic of Congo • Ethiopia • Gabon • Ghana • Guinea • Guinea-Bissau • Guinea-Conakry • Kenya • Liberia • Madagascar • Malawi • Mali • Mozambique • Namibia • Nigeria • Rwanda • Senegal • South Africa • Sudan • Tanzania • The Gambia • Togo • Uganda • Zambia • Zimbabwe

  4. Strengthening of clinical trials capacity and the enabling environment 2 1 3 6 4 5

  5. EDCTP Regional Networks for Clinical Trials Western Africa: WANETAM Website: www.wanetam.org Project Coordinator: Prof. Soleymane Mboup • Burkina Faso • The Gambia • Ghana • Guinea-Bissau • Mali • Nigeria • Senegal • United States Central Africa: CANTAM Website:www.cantam.org Project Coordinator: Prof. Francine Ntoumi • Cameroon • Congo, Republic of the • Gabon • France • Germany Eastern Africa: EACCR Website:www.eaccr.org Project Coordinator: Dr Pontiano Kaleebu • Kenya • Sudan • Ethiopia • Tanzania • Uganda • Germany • Sweden • United Kingdom • United States Southern Africa: TESA Website: www.tesafrica.org Project Coordinator: Dr Alexander Pym • Botswana • Malawi  • Mozambique  • South Africa  • Zambia  • Zimbabwe  • France • Germany • Netherlands • United Kingdom

  6. Funded projects including clinical trials 2003-2011 EDCTP has funded 174 projects in 29 African countries including 56 clinical trials on HIV/AIDS, malaria and TB

  7. HIV/AIDS treatment and prevention trials • Evaluation of paediatric formulations: fixed drug combinations/scored dispersible tablets • Evaluation of second-line treatment • HIV/TB co-infections • Prevention of Mother to Child Transmission of HIV (PMTCT)

  8. HIV preventive vaccine trials • Capacity building in preparation for • HIV vaccine trials- Joint EDCTP/BMGF • grant • DNA+MVA-CMDR (rgp 140/GLA-AF) phase I/II clinical trial (TaMoVac + AfrEVacc) in healthy young adults • DNA + MVA-HIVA phase I/II in healthy infants born to HIV1 and HIV2 uninfected and infected mothers

  9. Microbicide trials • Site preparation/capacity strengthening • Establishment of cohorts • Characterisation of novel safety markers • PRO 2000 vaginal gel phase III clinical trial

  10. EDCTP-II • Consolidation of the current focus on clinical trials • Phase II and III clinical trials • Expansion to phase I and IV clinical trials • Health services/optimisation studies • Neglected Tropical Diseases including co-morbidities • Open collaborative projects with other developing countries beyond sub-Saharan Africa

  11. Thank you http://www.edctp.org

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