Reclast Infusion Center Analysis August 4, 2008

1. ReclastInfusion Center AnalysisAugust 4, 2008

2. Key Findings • 93% of Bone-Uro and Geigy targets have infusion access within 10 miles. However, the number infusion centers might not be sufficient to meet patient needs in a region or a district. • 45.1K targets have infusion access within 10 miles • 3.3K targets do not have infusion access within 10 miles • There is a positive relationship between Reclast sales and the number of infusion centers • As the number of infusion centers increases, Reclast sales increase

3. Infusion Center Access in Geigy Regions

4. Geigy Region: Atlanta • 5,821 targets have infusion access within 10 miles (black dots) • 428 targets do not have infusion access within 10 miles (red triangles)

5. Geigy Region: Boston • 4.606 targets have infusion access within 10 miles (black dots) • 218 targets do not have infusion access within 10 miles (red triangles)

6. Geigy Region: Chicago • 7,426 targets have infusion access within 10 miles (black dots) • 550 targets do not have infusion access within 10 miles (red triangles)

7. Geigy Region: Cincinnati • 6,339 targets have infusion access within 10 miles (black dots) • 350 targets do not have infusion access within 10 miles (red triangles)

8. Geigy Region: Dallas • 5,661 targets have infusion access within 10 miles (black dots) • 573 targets do not have infusion access within 10 miles (red triangles)

9. Geigy Region: Morristown • 4,828 targets have infusion access within 10 miles (black dots) • 278 targets do not have infusion access within 10 miles (red triangles)

10. Geigy Region: Raleigh • 5,141 targets have infusion access within 10 miles (black dots) • 512 targets do not have infusion access within 10 miles (red triangles)

11. Geigy Region: San Ramon • 5,109 targets have infusion access within 10 miles (black dots) • 307 targets do not have infusion access within 10 miles (red triangles)

12. Relationship between Reclast Sales and Infusion Access Using Bone-Uro District Data

13. Bone/Uro Districts: Correlation between Reclast sales and Reclast Ready sites is 0.60 • There is a positive association between Reclast sales and Reclast Ready sites Data ending June 2008

14. Bone/Uro Districts: Correlation between Reclast sales and estimated 65+ women patients per Reclast Ready facility is -0.76 • There is a positive association between sales and Reclast Ready sites Estimated 65+ Women Patients = 55% of 65+ Women Data ending June 2008

15. Bone-Uro Districts: Correlation between estimated 65+ women patients and oral BP TRxs is 0.90 but correlation between 65+ Women patients and Reclast sales is only 0.42 Estimated 65+ Women Patients = 55% of 65+ Women Data ending June 2008

16. Back-UpInfusion Center Access in Bone-Uro Districts