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girls exploring physics. meiosis. 13 February 2012. diploid. diploid number (2n): specific number of chromosomes in eukaryotic cells 46 for humans Mitosis produces diploid cells. haploid. haploid number (n): number of chromosomes in a gamete gamete: sex cell ( eg . sperm, ovum). how?.
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meiosis 13 February 2012
diploid • diploid number (2n): • specific number of chromosomes in eukaryotic cells • 46 for humans • Mitosis produces diploid cells
haploid • haploid number (n): • number of chromosomes in a gamete • gamete: • sex cell (eg. sperm, ovum)
how? • Gametes are haploid (n) cells, and mitosis forms diploid (2n) cells, so gametes cannot be formed by mitosis. • meiosis
interphase • cell growth • DNA replication • DNA loosely coiled in chromatin form • nuclear membrane intact
prophase I • spindle forming • chromatin condensing into chromosomes • nuclear membrane dissolving
metaphase I • pairs of chromosomes line up on opposite sides of metaphase plate • spindle attaches to individual chromosomes
anaphase I • homologous chromosomes pulled away to separate ends of cell • pairs are now separated
telophase I • cell begins to cleave in half • each pole of cell now has half the original number of chromosomes
interkinesis • haploid cells • similar to interphase • cell growth, protein formation • no DNA replication
prophase II • one chromosome of the homologous pair in each cell • chromatin condenses
metaphase II • chromosomes line up at metaphase plate like in mitosis
anaphase II • sister chromatids pulled apart at centromere • chromatids move to opposite poles of cell • once separate, each chromatid considered to be a chromosome
telophase II • spindle fibres begin to disappear • nuclear membrane forms around each set of chromosomes
cytokinesis • cells separate • now have four haploid cells
genetic variation • Why aren’t we identical? • Why aren’t brothers and sisters identical?
independent assortment • mathematically, there are more than 8 million possible combinations of 23 chromosomes • 2×2×2×2×… = 223
independent assortment • gametes combine (eg. sperm + egg) and there are more than 70 trillion possible combinations • 8 388 608 × 8 388 608 = 70 368 744 177 664
more variation • crossing over • before pairs of chromosomes are separated, they can ‘trade’ segments of DNA