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Daniel Erenso Department of Physics & Astronomy MTSU , Murfreesboro, TN 37132

“Recent advances in biomedical physics research at MTSU. Daniel Erenso Department of Physics & Astronomy MTSU , Murfreesboro, TN 37132. LT a novel optical device. Biomedical optics lab. Laser-visible (400-700nm). Laser-invisible (1064nm). Las er.

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Daniel Erenso Department of Physics & Astronomy MTSU , Murfreesboro, TN 37132

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  1. “Recent advances in biomedical physics research at MTSU Daniel Erenso Department of Physics & Astronomy MTSU, Murfreesboro, TN 37132

  2. LT a novel optical device Biomedical optics lab Laser-visible (400-700nm) Laser-invisible (1064nm) Laser …trap and manipulate dielectric objects as large as 100mm and as small as a single atom…

  3. Elasticity- RBCs… …6-8µm biconcave disk-shaped cells; 4x106-6x106/mm³; develop in the bone marrow and circulate for about 100–120 days… …deliver oxygen to body tissues by squeezing through the body’s capillaries with inner diameters as small as 3µm… …Compressing… …Stretching… MMC - Sickle Cell Center Dr. Aguinaga Dr. Mushi

  4. Elasticity- RBCs… Trap & release…(Normal vs treated SCA)… …RBCs elasticity… Measured parameters… Free dF normal & transfused vs power… Trapped dTmin dTmax Power, P

  5. Elasticity- cancer cells Trap & release… chemotherapy… A549 Lung cancer cells… Untreated,3 hour treated,, 6 hour treated, …relaxation rate time constant… free trapped Dr. W. Stewart Neuroblastoma, Breast cancer cells Dr. Y Gao

  6. Cell ionization ….RBCs ionization…! The ionization energy The charge ….Cancer cells ionization…!

  7. Cell ionization-Radio-dosymetry Ionization of BT20-Breast Cancer cells… Displacement for ejected 50 BT20 breast cancer cells as measured from the center of the trap as a function of time M. Kelly

  8. Cell ionization-Radio-dosymetry Ionization of BT20-Breast Cancer cells… Theory model-cell membrane dielectric breakdown…

  9. Cell ionization-Radio-dosymetry …Ionization of Breast Cancer cells…(BT20)… Distribution of (a) the charge measured in units of e (magnitude of the charge of the electron) per BT20 breast cancer cell with bins width is 50e and (b) the incident ionization energy per cell in mJ andper unit mass in J/μgwith same bin size of 0.2mJ (J/μg). The color coded graphs in (c) displays the corresponding cumulative probabilities. The total number of cells is 50

  10. Cell ionization- Radiation emission...! • Our theory… an oscillating or accelerating charges and oscillating current can generate radiations • Radiation intensity…the flow of energy/area/time • Undiluted blood…. Clip 1a -AFC-01/22/16 Clip 1b-AFC-01/23/16 (Same slide) • Diluted blood..... Clip 1b -AA-06/10/16

  11. Cell ionization- can it be done by sunlight...? • Focus/collimate sunlight by lenses • Form a trap at ~3W • Blood in a metallic spherical cavity rotating with a variable angular acceleration • Ionization/plasma/radiation • Trapped radiation/heat energy

  12. Conclusion Remarks • Research in single cancer cell Radiodosymetry-in radiotherapy and radio-chemotherapy… Continued…!!! • Research in RBCs elasticity/Ionization/radiation/energy…. Suspended…

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