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รายงานการลาศึกษาต่อระดับปริญญาเอก เรื่อง cardiorenal syndrome

รายงานการลาศึกษาต่อระดับปริญญาเอก เรื่อง cardiorenal syndrome ณ Monash University, Australia (2008-2012). ผศ. พญ. สุรีย์ เลขวรรณ วิจิตร 15 May 2012. Cardiorenal syndrome.

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รายงานการลาศึกษาต่อระดับปริญญาเอก เรื่อง cardiorenal syndrome

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  1. รายงานการลาศึกษาต่อระดับปริญญาเอก เรื่อง cardiorenal syndrome ณ Monash University, Australia (2008-2012) ผศ.พญ.สุรีย์ เลขวรรณวิจิตร 15 May 2012

  2. Cardiorenal syndrome Hypothesis1: Indoxyl sulfate has adverse cardiac effects.Hypothesis2: MI causes renal function and structural changes over time. Increased CV morbidity & mortality Pathologic remodeling Diminished blood flow Neurohormonal activation Vasoconstriction hemodynamics Oxidative stress Diuretic therapy Inflammation Neurohormonal activation Anemia non-dialyzable uraemic toxins? Indoxyl sulfate (IS)

  3. Cardiac fibroblast Indoxyl sulfate: In vitro study Cardiac myocyte Collagen synthesis Protein synthesis THP-1 cell: Pro-inflammatory cytokine gene expression

  4. Indoxyl sulfate: In vivo study AST-120 GI tract Indoxyl sulfate (circulation) OAT1 and 3 urine

  5. Cardiac Fibrosis Sham STNx+Vehicle STNx+AST-120 0.8X 0.8X 0.8X

  6. Renal changes post-MI: In vivo study

  7. In vivo MI–AST120 study Background MI (16 weeks) renal fibrosis

  8. Serum IS Results Heart Kidney

  9. Publications • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? Eur Heart J 2010;31(14):1771-1779. • Krum H, Iyngkaran P, Lekawanvijit S. Pharmacological Management of the Cardiorenal Syndrome in Heart Failure. Current Heart Failure Reports 2009;6:105-111. • Lekawanvijit S, Kompa AR, Zhang Y, Wang BH, Kelly DJ, Krum H. Myocardial Infarction Impairs Renal Function, Induces Renal Interstitial Fibrosis and Increases renal KIM-1 Expression: Implications for Cardiorenal Syndrome. Am J Physiol Heart Circ Physiol. 2012 Feb 24. [Epub ahead of print] • Liu S, Lekawanvijit S, Kompa AR, Wang BH, Kelly DJ, Krum H. Cardiorenal Syndrome: Pathophysiology, Preclinical Models, Management and Potential Role of Uraemic Toxins. Clin Exp Pharmacol Physiol. 2011 Oct 20. doi: 10.1111/j.1440-1681.2011.05632.x. [Epub ahead of print] • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. (Under review at PLOS One) Presentation title

  10. Conference communications • Lekawanvijit S, Kompa A, Wang BH, Nishijima F, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate Reducing Circulating Levels of Indoxyl Sulfate, a Non-Dialysable Uremic Toxin, Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis. In: The Japanese Circulation Society 16-18 March 2012. Fukuoka, Japan. • Lekawanvijit S, Kompa AR, Manabe M, Kelly DJ, Krum H. Reduction of renal fibrosis as well as cardiac pro-fibrotic and pro-inflammatory mRNA expression by an oral charcoal adsorbent, AST-120, in post-MI rats. In: The American Heart Association Scientific Sessions 12-16 November 2011. Orlando, Florida, USA. • Lekawanvijit S, Kompa A, Wang BH, Nishijima F, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The ASN Kidney Week, 8-13 November 2011, Philadelphia, Pennsylvania, USA. • Lekawanvijit S, Kompa AR, Manabe M, Kelly DJ, Krum H. Reducing circulating levels of a non-dialysable uraemic toxin, indoxyl sulfate, ameliorates chronic kidney disease-induced cardiac fibrosis. In: The European Society of Cardiology Congress 2011. Paris, France; European Heart Journal 2011, 32 (Abstract Supplement):1002. • Lekawanvijit S, Kompa AR, Manabe M, Wang BH, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The CSANZ 59th Annual Scientific Meeting. Perth, Australia; Heart, Lung and Circulation 2011, 20;S61. • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. An oral charcoal adsorbent, AST-120, reduces renal fibrosis as well as cardiac pro-fibrotic and pro-inflammatory mRNA expression post-MI in the rat. In: The CSANZ 59th Annual Scientific Meeting. Perth, Australia; Heart, Lung and Circulation 2011, 20;S58. • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The American College of Cardiology 60th Annual Scientific Session and i2 Summit, April 2-5, 2011, New Orleans, Louisiana, USA; J Am Coll Cardiol 2011; 57:192.

  11. Conference communications (cont.) • Lekawanvijit S, Kompa A, Manabe M, Kelly DJ, Krum H. Chronic Kidney Disease-Induced Cardiac Fibrosis is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uraemic Toxin, Indoxyl Sulfate. In: The 44ht Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Annual Scientific Meeting. Melbourne, Australia. 28 November – 1 December, 2010. • Lekawanvijit S, Kompa A, Zhang Y, Wang BH, Kelly DJ, Krum H. Myocardial infarction impairs renal function, induces renal interstitial fibrosis and increases Kim-1 expression: Implications for the cardiorenal syndrome. In: The CSANZ 58th Annual Scientific Meeting. Adelaide, Australia; Heart, Lung and Circulation 2010, 19;S76-77. • Lekawanvijit S, Kompa A, Zhang Y, Wang BH, Kelly DJ, Krum H. Myocardial infarction impairs renal function, induces renal interstitial fibrosis and increases Kim-1 expression: Implications for the cardiorenal syndrome. In: The American Heart Association Scientific Sessions 2009. Orlando, Florida, USA; Circulation 2009, 120:S1076. • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? In: The CSANZ 57th Annual Scientific Meeting. Sydney, Australia; Heart, Lung and Circulation 2009, 18(suppl 3);S174. • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? In: The American Heart Association Scientific Sessions 2008. New Orleans, Louisiana, USA; Circulation 2008, 118(suppl 2):S338. • Lekawanvijit S, Adrahtas A, Kelly DJ, Kompa AR, Krum H, Wang B. Does Indoxyl Sulfate, A Uraemic Toxin, Have Direct Effects on Cardiac Fibroblasts & Myocytes? In: The Alfred Week Research Poster Display. 20-24 October, 2008.

  12. Acknowledgements Supervisors • Professor Henry Krum • Professor Darren Kelly • Dr. Andrew Kompa • Dr. Bing Wang • Monash University • University of Melbourne • Prince Doctor Fund • Faculty of Medicine • Chiang Mai University • Thailand

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