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Ce ll- Cu lture real time Mo nitoring system Analog Design Contest 2013

Cecumo. Ce ll- Cu lture real time Mo nitoring system Analog Design Contest 2013 Team: José A. Maldonado, Juan N. Olmo , Gloria Huertas , Alberto Yúfera. “ The important thing is not to stop questioning” . Albert Einstein. Agenda. Motivation Theoretical background Simulations

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Ce ll- Cu lture real time Mo nitoring system Analog Design Contest 2013

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  1. Cecumo Cell-Culture real time Monitoring system Analog Design Contest 2013 Team: José A. Maldonado, Juan N. Olmo, Gloria Huertas, Alberto Yúfera “The important thing is not to stop questioning”. Albert Einstein

  2. Agenda • Motivation • Theoreticalbackground • Simulations • Systemdescription • Implementation • Features • Results • Final conclusions • Questions and comments AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  3. Motivation AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  4. Theoreticalbackground Low-Pass Behaviourfunction of cell-culture occupationarea (Ac) AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  5. Theoreticalbackground: simulations AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo Oscillation-BasedTest approach

  6. Systemdescription: implementation AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  7. Systemdescription: results AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  8. Systemdescription: results AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  9. Systemdescription: features • Real time monitoring • “Cell friendly” (Max. 30mV/30μA) • Immediate result • Up to 8 cultures • Wireless connectivity • Data logging • Long battery lifetime (100mA/10mA@±5V) • Compact and light-weight design (160x80x25mm) AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  10. Conclusions • Lowcost & reusable “biological” oscillatorforCell Culture growingmeasurements. • Amplitude and frequencytocharacterizeoccupation. • AGC forbetternoiseinmunity • Frequency and AGC control voltage (Vg) toextractFill Factor (ff) parameter. • Potential fields of application: medicine and biology AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  11. Questions and comments Thank you for your attention! AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  12. Systemdescription: implementation • Band Pass Filter AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  13. Systemdescription: implementation • AGC AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  14. Systemdescription: implementation • BioZ Interface AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

  15. Systemdescription: implementation • High Pass Filter & Comparator AnalogDesignContest 2013 José A. Maldonado, Juan N. Olmo

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