1 / 11

Blood Studies Liver function test (LFT) Group of biochemical tests

Blood Studies Liver function test (LFT) Group of biochemical tests Uses of liver function test (LFTs) Differential diagnosis & prognosis of jaundice To assess the extend of liver damage To follow the progress of liver damage. Liver function test (LFT) Serum Bilirubin

kirk-padilla
Download Presentation

Blood Studies Liver function test (LFT) Group of biochemical tests

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Blood Studies Liver function test (LFT) • Group of biochemical tests Uses of liver function test (LFTs) • Differential diagnosis & prognosis of jaundice • To assess the extend of liver damage • To follow the progress of liver damage

  2. Liver function test (LFT) • Serum Bilirubin • Hepatic enzymes – AST, ALT, Alkaline Phosphatase • Prothrombin time • Serum proteins (with albumin & globulin ratio A/G ratio)

  3. 1. Serum Bilirubin 2. Serum Enzymes Serum Aminotransferase - AST (SGOT), ALT (SGPT) Elevated levels usually indicate cellular damage to the liver ALT – alanineamonitransferase • Cytosol enzyme • It is more specific than AST for the liver AST – asparateamninotransferaase • Mitochondrial enzyme • Also present in heart, brain, kidney & musles • High levels are seen in hepatic necrosis, myocardial infarction, muscle injury

  4. Alkaline phosphatase • Present in canalicular membranes of hepatocyte • Secreted in bile, Blockage of Alkaline Phosphatase excretion (via bile) will induce more synthesis, leading to high blood levels. • Raised in cholestatic jaundice (4-6 times normal) • Also raised in Metastatis & cirrhosis • Present in liver, bone , intestine & plasma Gamma glutamyltransferase (γGT) • Raised value is good guide to alcohol intake

  5. ProthrombinTime (PT) • Time required for a firm fibrin clot to form • It is a sensitive indicator of both acute & chronic liver disease • Prolonged PT occurs due to Vit K deficiency, which is excluded by giving 10mg of Vit K IV • In liver dysfunction, increase clotting time with increased risk of bleeding

  6. Protein Studies • Serum albumin • Low levels indicates severity of chronic liver disease • Falling serum albumin is a bad prognostic sign liver disease • Serum globulin • Hyperglobulinaemia occurs in chronic liver disease due to immunological mechanisms High globulin & low albumin is a characteristic feature of CLD

  7. Ammonia • Liver converts ammonia to urea. Ammonia rises in liver failure Tumor Marker • Alpha-fetoprotein (AFP) • Increased levels are seen with hepatic carcinoma Liver Biopsy • Used to obtain a specimen of liver tissue • Done under local anesthesia

  8. Imaging • USG of Liver

  9. Imaging • CT of Liver • MRI of Liver

  10. Cholangiography X-ray examination of the biliary system, using a radiopaque dye given intravenously or orally, as contrast medium Types • Oralcholecystography /OCG • Intravenous cholangio graphy/ICG • Endoscopic Retrograde Cholangio – Pancreatography /ERCP • Percutaneous transhepatic cholangiography /PTC • Operative cholangiography • Operative T tube cholangiography Dr S Chakradhar

  11. Magnetic Resonance cholangio-pancreatography/MRCP Dr S Chakradhar

More Related