Practical Implications of Sleep Neurochemistry

1. Practical Implications of Sleep Neurochemistry LASM November 2011 Kevin R. Hargrave, MD CNS Clinic, Lafayette LA

2. Practical Implications of Sleep Neurochemistry • Intro comments (3-15) • Rx’s: top 5 in U.S. and most common of CNS clinic pt’s (16-27) • Anatomy of sleep related neuronal centers/circuits (28-49) • Wake circuitry • Sleep NREM circuitry • REM circuitry • Brain Chemistry and sleep stages (49-89) • Wake neurochemicals • NREM neurochemicals • REM neurochemicals • Conditions (sleep d.o.’s) and tidbits thereof (90-105) • Drugs (effects on sleep) (106-130)

4. ‘Sleep’ According to Dr. Dement, Sleep: Two essential features • Perceptual wall bw conscious mind and outside world • Immediately reversible And the brain “puts itself to sleep” According to Freud, from his 1905 book Interpretation of Dreams, dreams represent “the royal road to a knowledge of the part the unconscious plays in mental life”

5. As late as 1970, the practice of medicine ended when the patient fell asleep.

6. Practical Implications of Sleep Neurochemistry Anatomy (brain anatomy as it pertains to sleep) Brain Chemistry (W, NR, R and their Nchem’s Conditions (sleep d.o.’s) Drugs(Rx’s and their effects on sleep)

7. Sleep/Wake Neuroanatomy: SCN (anterior hypothalamus) Sleep Review Sept 2011

8. Sleep/Wake Neuroanatomy http://courses.washington.edu fly Neurochemistry of Sleep and Wakefulness. Monti et al. Genes Dev. 2010 Jun 15;24(12):1220-35.

9. . Tamakawa Y et al. J Neurophysiol 2006;95:2055-2069 ©2006 by American Physiological Society

10. . Tamakawa Y et al. J Neurophysiol 2006;95:2055-2069 ©2006 by American Physiological Society

11. pubs.niaaa.nih.gov