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Teachable Tidbit: Cell Signaling—Why should YOU Care?

Teachable Tidbit: Cell Signaling—Why should YOU Care?. Mountain West Summer Institute August 3, 2012 Group 1: Cell Biology. Participants: Patrick Burns, Jacquelyn Duke, Diane Hartman, Pamela Harvey, Andrea Stith, and Mark Thomas Facilitators: Renee Dawson and Robin Wright.

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Teachable Tidbit: Cell Signaling—Why should YOU Care?

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  1. Teachable Tidbit: Cell Signaling—Why should YOU Care? Mountain West Summer Institute August 3, 2012 Group 1: Cell Biology Participants: Patrick Burns, Jacquelyn Duke, Diane Hartman, Pamela Harvey, Andrea Stith, and Mark Thomas Facilitators: Renee Dawson and Robin Wright

  2. Overview • Topic: Cell signaling and cancer • Context: • Week-long unit geared toward 100-level biology course for majors and non-majors. • End of semester • 50 to 100 students • Prior Knowledge: • Cell structure • Mitosis • Reading assignment on cell signaling

  3. Unit Goals • Understand that cell signaling regulates cell division • Understand that defects in cell signaling underlie cancer

  4. Tidbit: Outcomes & Activities

  5. What do these people have in common?

  6. What IS cancer? • Will there ever be a cure?

  7. Cell Division and Cancer

  8. Cell Division Go STOP

  9. Cell Division A B C ___Transduction Pathway ___Nuclear Envelope ___Plasma Membrane ___Growth Factor Receptor ___Growth Factor ___Tumor Suppressor Gene Go D E F STOP

  10. Regulators of Cell Division

  11. Summary Assessment Question Jane recently was diagnosed with breast cancer. The oncologist performed a biopsy and laboratory analysis revealed an increase in HER2 receptors and decreased p53. You work in a pharmaceutical company and are a genius at drug design. Brainstorm a way to treat Jane’s cancer.

  12. Take home messages: Appropriate cell signaling is required for normal cell division. Cancers are caused by defects in cell signaling pathways. Multiple defects magnify the severity.

  13. Assessment, Alignment, & Diversity

  14. Thank you! Facilitators, Group Members & National Academies Summer Institute for your contributions!

  15. Website Citations • 1 http://trussty-jasmine.blogspot.com/2012/03/stem-cells-can-repair-damaged-corneas.html#axzz22P5vt5SP • 2 http://www.buyactivatedcharcoal.com/infected_wounds • 3 http://en.wikipedia.org/wiki/Human_skeleton

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