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Extra credit

Extra credit. Extra credit 1 – ionic radii trends Extra credit 2 – solving MIMT single crystal structures Work on these must be completed individually . Due date: May 14 th. Exploring biological functionality. Enzymes Complex systems that often contain metals at active site

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Extra credit

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  1. Extra credit • Extra credit 1 – ionic radii trends • Extra credit 2 – solving MIMT single crystal structures • Work on these must be completedindividually. • Due date: May 14th

  2. Exploring biological functionality • Enzymes • Complex systems that often contain metals at active site • Metals are particularly import for redox enzymes • Bio-inorganic chemistry • Synthesis of model compounds

  3. The biological nitrogen cycle

  4. Nitrogenase Nitrogenase consists of 2 proteins: dinitrogenase reductase and dinitrogenase Overall reaction dinitrogenase reductase dinitrogenase 16 ATP required for each reduction of N2 -> 2 NH3

  5. Some bacteria fix nitrogen only when involved in a symbiotic relationship with plants

  6. Leghemoglobin protects nitrogenase by binding oxygen A true cross-species collaboration: Plant makes the globin protein and bacterium makes the heme cofactor

  7. Industrial Haber process (N2 -> NH3) T = 400-500 °C p = 300-1000 atm

  8. Dinitrogenase model compound

  9. Oxygen binding in body

  10. You will make model compound, Co(salen) • Co(salen) can bind oxygen, just like the biological heme molecule

  11. Oxygen binding depends on Co environment • In crystals: • Solvated: • Co(salen) exists with Co in a 4, 5, or 6 coordinate site • Solvated Co(salen) only binds O2 when it is 5 or 6 coordinate

  12. Experimental apparatus for measuring O2 binding

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