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Molecular Level Assembly of Novel BioHybrid Materials Jonathan S. Dordick (RPI)

Molecular Level Assembly of Novel BioHybrid Materials Jonathan S. Dordick (RPI). NSF Nanoscale Science and Engineering Center for Directed Assembly of Nanostructures Rensselaer Polytechnic Institute, DMR 0642573. Richard Siegel, Rensselaer Polytechnic Institute, DMR 0642573.

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Molecular Level Assembly of Novel BioHybrid Materials Jonathan S. Dordick (RPI)

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  1. Molecular Level Assembly of Novel BioHybrid Materials Jonathan S. Dordick (RPI) NSF Nanoscale Science and Engineering Center for Directed Assembly of Nanostructures Rensselaer Polytechnic Institute, DMR 0642573 Richard Siegel, Rensselaer Polytechnic Institute, DMR 0642573 Mimicking the principles learned from Nature’s microtubules can lead to the next generation of materials with improved mechanical efficiency and a wide range of functional properties. Dinu, Dordick et al. (Advanced Materials 2009; Small 2009) have shown that biological function can be conferred to carbon nanotubes. Specifically, direct attachment of tubulin dimer cytoskeletal protein (schematically shown in green and violet) onto multi-wall carbon nanotubes (MWNTs, shown as graphite cylinders) form tubulin-MWNT conjugates. The geometries of these conjugates are a function of the tubulin concentration (AFM image of flowerlike geometry). MWNT-templated tubulin undergoes self-assembly with free tubulin in solution to yield functional nano- and mesoscale architectures, including biohybrids of microtubule-encapsulated nanotubes. These could be manipulated in synthetic, non-physiological environments by surface-attached kinesin molecular motors to create new sensors or actuators.

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