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MOTHER-TO-CHILD HIV TRASMISSION. SOCIAL LIMITS TO AN EFECTIVE BIOMEDICAL RESPONSE

MOPE0527. MOTHER-TO-CHILD HIV TRASMISSION. SOCIAL LIMITS TO AN EFECTIVE BIOMEDICAL RESPONSE Associated factors with the vertical transmission in Buenos Aires City. 2003/2006 Nan, M .; Basombrío, A.; Bloch, C.; Bruno, M.; Durán, A.; Ivalo, S.; Vila, M.; Vulcano, S.

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MOTHER-TO-CHILD HIV TRASMISSION. SOCIAL LIMITS TO AN EFECTIVE BIOMEDICAL RESPONSE

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  1. MOPE0527 MOTHER-TO-CHILD HIV TRASMISSION. SOCIAL LIMITS TO AN EFECTIVE BIOMEDICAL RESPONSE Associated factors with the vertical transmission in Buenos Aires City. 2003/2006 Nan, M.; Basombrío, A.; Bloch, C.; Bruno, M.; Durán, A.; Ivalo, S.; Vila, M.; Vulcano, S. Coordinación SIDA, Ministerio de Salud del Gobierno de la Ciudad de Buenos Aires coordinacionsida@buenosaires.gov.ar Grant by Global Fund to fight AIDS, Tuberculosis and Malaria : Argentinian Project BACKGROUND In developed countries the success of preventive interventions for mother-to-child transmission (MTCT) of HIV has resulted in transmission rates of less than 2%. Despite the fact that the Health System in Buenos Aires City (CABA) provides global care and treatment to pregnant women with HIV infection and their infants, the MTCT rate was 4.2% during 2003-2006. OBJECTIVES - To analyze the factors associated to vertically acquired HIV in all infected children born in the public system during 2003-2006 period. - To examine associated factors for MTCT looking for differences between infected and no infected mother-child pairs. MATERIAL & METHODS Case-Control study of HIV exposed children born in public hospitals during 2003-2006. Review of clinical charts of all infected children and their mothers and of stratified, probabilistic sample of exposed non-infected children and their mothers . Both groups were obtained from the same database. RESULTS Forty one cases of infected children were detected during this period .A probabilistic sample of exposed 241 non-infected children was selected TEMPORAL RELATIONSHEP BETWEEN PREGNANCY AND HIV DIAGNOSIS PRENATAL CARE X2 = 55.7 p< 0.001 ARV PROPHYLAXIS AT LABOUR PRENATAL ARV PROPHYLAXIS 53.7% X2 = 66.1 p< 0.0001 X2 = 51 p< 0.0001 36.6% 9.8% OR FOR FACTORS ASSOCIATED TO PERINATAL TRANSMISSION BREASTFEEDING CONCLUSIONS These results confirm the effectiveness of preventive interventions and show that an adequate prenatal care and early diagnosis of HIV infection during pregnancy are necessary conditions in order to decrease MTCT HIV infection to optimal rates

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