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Postsynaptic Membrane

2+. 2+. Ca. out. Ca. Co-localization by ACh and SP. Presynaptic Terminal. Vesicle. Vesicle. Sp. ACh. v. v. S. Sp. ACh. f. f. ACh-E. SP. -Enz. Synaptic cleft. c. SP. c. ACh. c. Enz. E. SP. -R. NK1. ACh. R. c. SP. -R. p. NK1. R. NK3. c. Ion Channels. R.

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Postsynaptic Membrane

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  1. 2+ 2+ Ca out Ca Co-localization by ACh and SP Presynaptic Terminal Vesicle Vesicle Sp ACh v v S Sp ACh f f ACh-E SP -Enz Synaptic cleft c SP c ACh c Enz E SP -R NK1 ACh R c SP -R p NK1 R NK3 c Ion Channels R NK3 Ion Channels SP -R -G c NK1 G ACh-R PhC PhC i a P Postsynaptic Membrane PkC Dg PkC i a PPhos P + IP 3 PIP IP -R 3 3 ER R ER Pr 2+ Ca ier Endoplasmic Reticulum

  2. Concomitant activation of the m 1 type ACh receptor, and … … the NK1 type receptor Effect of activation of the m 1 type ACh receptor

  3. Effect of activation of the m 1 type ACh receptor Concomitant activation of the m 1 type (ACh) and NK 1 type receptors Activation of the NK 2 type receptor

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