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Exhaled Breath Measured using Tunable Diode Laser Absorption Spectroscopy (TDLAS)

Exhaled Breath Measured using Tunable Diode Laser Absorption Spectroscopy (TDLAS). Patrick J. McCann, Ph.D. Ekips Technologies, Inc. Norman, OK School of Electrical and Computer Engineering University of Oklahoma Norman, OK. ATS Workshop Toronto, Canada December 14, 2002.

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Exhaled Breath Measured using Tunable Diode Laser Absorption Spectroscopy (TDLAS)

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  1. Exhaled Breath Measured using Tunable Diode Laser Absorption Spectroscopy (TDLAS) Patrick J. McCann, Ph.D. Ekips Technologies, Inc. Norman, OK School of Electrical and Computer Engineering University of Oklahoma Norman, OK ATS Workshop Toronto, Canada December 14, 2002 www.breathmeter.com

  2. Molecules absorb infrared light: Simultaneous NO and CO2 detection: 1 Laser Chip Detector 2 Laser Chip Detector 1 3 Laser Chip Detector 2 Spectral Signals H2O+CO2 Vibrational Frequency ( ~ 5.2 µm) CO2 NO 3 Tunable Diode Laser Absorption Spectroscopy (TDLAS) • Self-calibrating sensor • Patient’s own CO2 is the calibration gas

  3. Breath Flow Laser Light Path (l ~ 5.2 mm) Laser and Detector Assembly Exhaled Breath Flowing through Gas Cell Single Exhalation Against Resistance (10-20 sec) eNO Measurements with TDLAS Results displayed in real-time (video)

  4. Asthmatic Examples Age 5, Female, Mild-Persistent Corticosteriod Treated Age 14,Male, Mild-Persistent Non-Treated Normal Airway Inflamed Airway

  5. Treatment Monitoring

  6. Important question for polluted areas Group of Vehicles Stopped at Intersection Street Level NO (Norman, OK) High Emission Vehicles Individual Vehicles Typical eNO Range (5-70 ppb) Air Pollution Effects? • Nitric Oxide is a major component of smog. • Automobile exhaust is primary source. • Ambient NO (aNO) concentrations will vary with geography, weather conditions (inversion layers), and time of day.

  7. eNO not Affected by aNO Untreated Asthmatic Untreated Asthmatic Non- Asthmatic Non- Asthmatic Ambient Air Displaced by Breath Low aNO (2 ppb) High aNO (24 ppb)

  8. Acetaldehyde is an alcohol metabolite End Consumption Measured in breath during and after dinking Molson Golden™ Begin Consumption Other Molecules • TDLAS can rapidly measure many different small heteronuclear molecules. • Compounds measured by the OU/Ekips team in the last 3 years:CO, COF2, NO, N2O, NH3, CH4, C2H2, CS2, SO2, H2O, HDO, H2O2, 12CO2, 13CO2, C7H8 (toluene), C6H6 (benzene), CH2O (formaldehyde), C2H4O (acetaldehyde), C6H6O (phenol), C3H6O (acetone), and CH2Cl2 (methylene chloride)

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