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10 11 neurons (10 5 per mm 3 ) 10 15 synapses

10 11 neurons (10 5 per mm 3 ) 10 15 synapses. Electrical signals come IN to dendrites, are “integrated” in cell body, result goes OUT axon. mitral cell (olfactory bulb). motor neuron (spinal cord). dendrite. Pyramidal cell (cortex). cell body. axon. Purkinje cell (cerebellum).

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10 11 neurons (10 5 per mm 3 ) 10 15 synapses

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  1. 1011 neurons (105 per mm3) 1015 synapses

  2. Electrical signals come IN to dendrites, are “integrated” in cell body, result goes OUT axon mitral cell (olfactory bulb) motor neuron (spinal cord) dendrite Pyramidal cell (cortex) cell body axon Purkinje cell (cerebellum) From Nicholls et al, 1992, Fisher and Boycott, 1974, Johnston and Wu, 1997

  3. Given sufficient input, neurons “fire action potentials” – fast voltage transients INPUT DENDRITES Voltage V: set by "excess charge" inside vs outside membrane (more later) CELL BODY Action potential ~100 mV OUTPUT AXON 0 10 msec Johnston and Wu, 1997

  4. Given sufficient input, neurons “fire action potentials” – fast voltage transients …which are communicated to downstream neurons via synapses INPUT CHEMICAL SYNAPSE CELL BODY mV OUTPUT 0 10 msec AXON 0 10 msec Johnston and Wu, 1997

  5. FIGURES FROM: THEORETICAL NEUROSCIENCE, Abbott and Dayan, MIT Press

  6. FIGURES FROM: THEORETICAL NEUROSCIENCE, Abbott and Dayan, MIT Press

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