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Leslie Raffel, MD Associate Director and Cedars-Sinai Site Director,

Leslie Raffel, MD Associate Director and Cedars-Sinai Site Director, UCLA Clinical & Translational Science Institute. UCLA CTSI Clinical and Translational Science Institute. NIH/ Career Development Award Workshop February 13, 2014. www.ctsi.ucla.edu. UCLA CTSI Goals. NIH CTSA Consortium.

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Leslie Raffel, MD Associate Director and Cedars-Sinai Site Director,

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  1. Leslie Raffel, MD Associate Director and Cedars-Sinai Site Director, UCLA Clinical & Translational Science Institute UCLA CTSI Clinical and Translational Science Institute NIH/ Career Development Award Workshop February 13, 2014 www.ctsi.ucla.edu

  2. UCLA CTSI Goals

  3. NIH CTSA Consortium

  4. What is translational research? • UCLA CTSI translational investigation extends from molecules to society • Translating knowledge gained from laboratory science into clinical practice to improve health. • The aim of translational research is to produce new: • therapeutics • medical devices • tools for diagnosing disease • avenues for community engagement research 4

  5. Program Areas (1-5) 1) Clinical and Community Research Resources (CCRR) 2) Biomedical Informatics Program (BIP) 3) Community Engagement in Research Program (CERP) 4) Pilot and Collaborative Translational and Clinical Studies Programs (Pilot) 5) Research Education, Training and Career Development Program (CTSI-ED) 5

  6. Program Areas (6-10) 6) Biostatistics and Computational Biology Program 7) Center for Translational Technologies (CTT) 8) Maternal, Child and Adolescent Health (MCAH) 9) Regulatory Knowledge, Industry Relations and Research Ethics Program (Regulatory) 10) Evaluation & Tracking 6

  7. Early Career Awards

  8. KL2 Y1 Awardees Amira Brown, MS, PhD Assistant Professor, CDU “ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice” Joshua Zaritsky, MD, PhD Assistant Professor, Pediatric Nephrology, UCLA “ Hepcidin and the Anemia of Chronic Kidney Disease” GelarehGabayan, MD, MSHS Assistant Professor of Medicine, UCLA/VA “ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults”

  9. KL2 Y2 Awardees James McKinnell, MD Assistant Professor, UCLA-Harbor / LA-BioMed “Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization” Mary Sehl, MD, PhD Assistant Professor, UCLA “Modeling of EMT/MET transitions in breast cancer stem cells” David Shackelford, PhD Assistant Professor, UCLA “Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer”

  10. KL2 Y3 Awardees Rebecca Dudovitz, MD, MSHS Assistant Professor, UCLA “Understanding the relationship between adolescent identity and substance use” Heather Jones, MD Assistant Clinical Professor, Cedars-Sinai Medical Center “Role of IL1-ß and the NLRP3 inflammasome in the development of hypoxemia in acute lung injury” Anne Walling, MD, PhD Assistant Professor, UCLA “Single fraction vs. multiple fraction radiation for patients with advanced cancer and painful bone metastases” Michael Shino, MD Clinical Instructor, UCLA “Mechanisms Of Allograft Injury And The Development Of Bronchiolitis ObliteransSyndrome After Lung Transplantation”

  11. KL2 Y3 Awardees David Merrill, MD, PhD Assistant Clinical Professor, UCLA “Relationship of physical activity to hippocampal structure and memory in MCI” Eliza Congdon, PhD Assistant Professor, UCLA “Gene expression profiles of ECT response in major depressive disorder” Joshua Pevnick, MD, MSHS Assistant Professor, Cedars-Sinai Medical Center “Minimizing errors in medication histories obtained at hospital admission” Piwen Wang, MD, PhD, MS Assistant Professor, Charles Drew University of Medicine and Science “Sensitization of castration-resistant prostate tumors to docetaxel treatment by green tea and quercetin”

  12. Clinical and Translational Research Center (CTRC) The CTRC at Cedars-Sinai Supports and supervises human studies and clinical trials in all therapeutic areas and within all age groups • 5 exam/consultation rooms • Bionutritionist • Sample processing laboratory • Experienced certified research nurses • Mobile nurses • Cost-sharing with reduced rates for new investigators CTRC-Wide Accomplishments • Clinical support for 426 new & existing projects • 9,048 out-patient & 5754 in-patient stays

  13. Biostatistics ·Core Services ·Pilot Funding ·Education Activities • Biostatistical Consults • 8442 hours of statistical support provided • Vouchers • Awarded 79 proposals • Pilot funding • Awarded 73 pilot grants • ($1.6 M in CTSI funds; $2.2 M institutional funds) • CTSI Education Activities • >90 participants in K Award Workshops • 27 submitted draft proposals for review • More than 450 publications that received CTSI support • Quarterly publicationawards Watch for RFA coming soon! newsletters banner “Cite It” card posters

  14. ·Los Angeles Data Repository ·UC Research Exchange UC Davis Los Angeles Data Repository (LADR) UC San Francisco UC Research Exchange (UC-ReX) Cedars-Sinai UCLA newsletters banner “Cite It” card UC Irvine UC San Diego

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