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Clayton Wiley, M.D./PhD

Clayton Wiley, M.D./PhD. Question 1. A 5-year-old girl presents with a ~6 week history of early morning headaches. Describe the findings in her MRI scan. T1. T1 plus contrast. T1 plus contrast. Question 2. What is your major differential diagnosis for posterior fossa tumors in children?.

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Clayton Wiley, M.D./PhD

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  1. Clayton Wiley, M.D./PhD

  2. Question 1 A 5-year-old girl presents with a ~6 week history of early morning headaches. Describe the findings in her MRI scan.

  3. T1

  4. T1 plus contrast

  5. T1 plus contrast

  6. Question 2 What is your major differential diagnosis for posterior fossa tumors in children?

  7. Answer • Ependymoma • Pilocytic astrocytoma • Medulloblastoma

  8. Question 3 An intraoperative consultation was requested and performed via telepathology. Describe the findings in the intraoperative smear preparation on the following representative snapshots obtained via the telepathology system.

  9. Question 4 What is your intraoperative diagnosis?

  10. Answer Medulloblastoma

  11. Question 5 A resection of the mass was performed. Describe the findings in the following representative permanent H&E slide. Click hereto view slide.

  12. Question 8 Describe the findings in the following immunohistochemical slides for synaptophysin and Ki-67. Click hereto view slide

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