Kim Witmer Senior Vice President Chief Financial Officer Michael Nunn, Ph.D. Executive Director

1. Kim Witmer Senior Vice President Chief Financial Officer Michael Nunn, Ph.D. Executive Director Research Development

2. Endocrinology Developmental Biology Neurobiology Metabolism Molecular Biology Cancer Aging Immunology Gene Therapy Stem Cells Plant Biology Cognitive Neuroscience Chemical Biology Biophotonics

3. Salk Institute Cancer Center • Founded by Jonas Salk in 1970 • Designated as NCI Basic Center in 1973 • Center includes 30 Faculty members • 200 Post-doctoral researchers • 50 Graduate research students • Cancer Center Director: Tony Hunter, Ph.D. • Cancer Center is distributed across Salk • 62% of Institute investigators participate in Center programs

4. Responding to the Fiscal Environment-2014 • Institutional: • Philanthropy • Revenue Diversification • Cost Savings & Efficiencies • Research Development: • Strategies • Innovation Grant Program • Advocacy

5. Operating Revenue by Source Note: Excludes subcontracts going out

6. Philanthropy • Increased direct support to Investigators • Increased bridge funding • Raised funds for 21 chairs for Cancer Center Investigators • Provided Developmental chairs for 5 new Cancer Center members • Found major donors to build new Core Resources • Biophotonics, Next Gen Sequencing and Bioinformatics • Target Cancer Center research in Capital Campaign

7. Revenue Diversification • Encourage Investigators to pursue all grant application options • Secured large foundation grant for multiple PI’s & Cores • Developed inter-institutional shared resources • Hired Director of Research Development

8. Major Administrative Costs Savings • Restructure Mailroom & Telecomm • Central Plant Upgrade – requires less maintenance • ARD – restructuring for efficiency • Procurement – savings • Worker’s Compensation Improvements • Renegotiation of Large Contracts

9. NIH applications, Awards and Success Rates

10. The Research Development Office • The office provides – • Stewardship and Coaching: Individual R01s Managing Change • Launching New Projects: Centers and Programs • Seed Funding • Advise Senior Leadership

11. Strategies for Success

12. Strategies for Success • The Right Opportunity • The Right Audience • Developing Agency Support Themes:

13. Agency Websites: NIH Guide

14. Award Search: NIH RePORTER

16. The Right Opportunity Challenges for Cancer Research: Success Rates

17. The Right Opportunity Agency websites –become a pro: funding opportunities ✪ NIH http://grants.nih.gov/grants/oer.htm • NSF http://nsf.gov/funding/ • CDMRP http://cdmrp.army.mil/funding/prgdefault.shtml • Grants.gov funded projects • NIH http://projectreporter.nih.gov/reporter.cfm • NSF http://nsf.gov/awardsearch/ ✪ CDMRP http://cdmrp.army.mil/search.aspx

18. Automated Funding Announcements: Agency or Commercial

19. The Right Audience Who will review your grant? This is ESSENTIAL information to have BEFORE you start writing …

20. NIH RePORTER: Click on the grant number

21. Study Section

22. http://public.csr.nih.gov/StudySections/Pages/default.aspx

24. Program Official

25. Developing Agency Support • The best time to contact a Program Director? – BEFORE YOU START – required 6 weeks before submission of grants >$500K – NIDDK asks for 3-6 months notice for large programs Other Topics: • Summary Statements • Etiquette • Negotiating an Award

26. The Research Development OfficeLeadership: Push vs. Pull Challenge for developing new projects and building teams • Pull: • Investigator has a project and/or team already developed • Push: • Outsider [President?, Chair?, Executive Director?] identifies collaborative research opportunities in line with faculty research interests

27. The ResearchDevelopment Office • The Push – • Match opportunities to PIs: • Find Leaders • Collaborators – Identify experts (preferably local) to build a team • Sell the project: • Know the competition • – Identify similar funding • Timing of Submission… use NIH RePORTER • P30 Program and External Advisory Board Meetings

28. The ResearchDevelopment Office • Sample RDEV projects at the Salk Institute: • NCI Cancer Center Renewals in 2008 and 2013 • Sanford Consortium: $43M facility award from CIRM • New Centers, complementing the CCSG • NINDS and NEI P30 awards … • CIRM Center of Excellence in Genomic Medicine

29. SeedFunding • Salk Innovation Grant Program • Established in 2006 with donor funding • Average expenditures $1 million/year • Awards up to $100K direct costs for one year • Internal peer review with option for outside critiques • 2 rounds/yr, @ 12 applications, 4 awards

30. Salk Innovation Grants: Leverage • Major new projects seeded by SIG funding: • $5 M Industry partnership program • $2 M ARRA Grand Opportunities Award • $4 M Foundation Award • $4 M for two new NIH R01s

31. SeedFunding • Cancer Center Pilot Grants • Initiated in 2009 • Uses NCI CCSG Developmental Funds • Supports Cancer Focus: • – Collaborations • both intra- and inter-programmatic • – Translational Research • external, or • using C3 resources (current RFA)

32. Advocacy–AffectingChange • Administrators can serve as liaison to leaders at • Federal and State Agencies – NIH, CIRM, etc. • Administrators can join advocacy and lobbying groups • – Association of Independent Research Institutes (AIRI) • Example: Special Council Review • of Well-Funded Investigators

33. H-index Analysis: Investigators from 4 Cancer Centers at AIRI Institutions

35. Analysis of NIH Competing Awards, 2002-2013

36. Summary • Management • Human Resources • Infrastructure • Development • Portfolio Diversification • Unrestricted funds • Foundation & corporations • Grant Development • Seed Funding • Advocacy

37. Questions • What is your state doing to support Cancer Research? • What management strategies have helped you conserve resources? • Are there alternative approaches to funding start-up projects? • Who you gonna call to change Federal or State policy?