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Warm Up (take out your homework)

Warm Up (take out your homework). Draw 5 boxes Draw the process of mitosis in each phase, and describe what is happening to the DNA in each phase. Interphase . Early Mitosis. Mid- Mitosis. Late Mitosis. Final Product. Assessment. Next Class: Growth and Development.

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Warm Up (take out your homework)

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  1. Warm Up (take out your homework) • Draw 5 boxes • Draw the process of mitosis in each phase, and describe what is happening to the DNA in each phase Interphase Early Mitosis Mid- Mitosis Late Mitosis Final Product

  2. Assessment • Next Class: Growth and Development

  3. Development: Growth & Differentiation Essential Questions • How are the bodys tissues and organs formed? • How can developmental problems lead to cancer? • How are technologies like stem cell therapies and cloning organisms related to developmental processes?

  4. Todays Objectives • Describe the role of differentiation in the development of a multicellular organism. • Describe the process that leads to differentiation of cells in a multicellular organism. • Review key concepts of the unit so far (growth & differentiation)

  5. Concept Review

  6. Vocab • Zygote: a fertilized egg • Phenotype: the observable traits of an organism

  7. Readings: Coordinating Growth Differentiation and the Expression of Genetic Info • What might happen if too little cell division takes place? • Injuries go unrepaired • Too much? • A tumor can develop

  8. 2) Most of us go through every stage in the same sequence. So what? So clearly there is some pretty good coordination of development going on.

  9. 3) What are the two possible explanations for why all cells with the same DNA don’t do the same thing? **DIFFERENTIAL GENE EXPRESSION** • Environments inside the cells differ. A substance in one part of the cytoplasm ends up in one daughter cell and not the other. This may change the activity of the genes in that cell. • Something outside the cell differs. A nearby cell may affect its neighbor’s gene expression.

  10. Define induction and give an example. An outside influence on differentiation that occurs when a group of cells can cause a neighboring group of cells to differentiate in a certain way. Example: eye tissue development Sweat glands, teeth, limbs, and feathers * See graphic

  11. 5) Why are we not 4 Foot wide brains? -Different cell types use different parts of their genetic material

  12. 6) How do environmental influences affect gene expression ? -Although all cells have the same genes, environmental influences inside and outside the cell cause certain genes to turn on and others to turn off. *Active gene is transcribed to mRNA for protein synthesis *Inactive gene is not transcribed

  13. VOCAB GAME • Try to get your partner to guess the vocabulary word by giving him or her the definition. Development Differential Gene Expression Growth Interphase Differentiation Mitosis Induction Senescence

  14. Concept Review

  15. Growth • Growth is a key component of development in which a multicellular organism increases in size due to an increase in the number of cells. • Mitosis produces an increase in the number of cells during development. (http://geneticssuite.net/files/Cell%20multiplication.jpg)

  16. The Cell Cycle – Life of a Cell • Interphase • Accounts for 90% of the life cycle of a cell • Cell metabolism is active, the cell grows and DNA is replicated before the cell divides • M Phase • Consists of Mitosis (division of the nucleus) and Cytokinesis (division of the cytoplasm)

  17. Mitosis results in how many daughter cells? A) 1 B) 2 C) 3 D) 4

  18. How do the daughter cells of mitosis compare with the parent cell genetically? A) different B) same C) some parts are different, some parts are the same D) I’m not sure

  19. DNA packaging in a eukaryotic cell • DNA wraps around proteins called histones to form chromatin fibers. Chromatin is the form in which genetic material takes during interphase. • Chromatin further condenses into a chromosome during the M phase of the cell cycle. (http://www.tutorvista.com/biology/types-of-chromosomes)

  20. Chromosome Structure • A duplicated chromosome consists of two sister chromatids (present during prophase and metaphase of mitosis) • Sister chromatids are joined at a centromere • Which is an attachment point for spindle fibers during mitosis • A chromosome consists of one chromatid after sister chromatids are pulled apart during mitosis

  21. Chromososmes are present in a condensed, visible (under the microsccope) form during A) All parts of the cell cycle B) Interphase only C) Mitosis only D) I’m not sure

  22. Interphase • Includes: • Growth of cell • Metabolism is active • DNA is replicated • “Spaghetti Stage”

  23. Early Mitosis • Chromosomes Condense • Nuclear envelope (membrane) disintegrate • Centrosomes migrate to poles • Spindle fibers appear

  24. Mid-Mitosis • Chromosomes line up along the equator (middle) of the cell

  25. Late Mitosis • Sister chromatids separate • Spindle fibers pull chromosomes to poles

  26. Final Result: 2 identical daughter cells • Chromosomes go to separate poles • Chromosomes unwind • Nuclear envelope reforms • Cytokinesis (cytoplasm division) is completed

  27. 1. 2. 4. 3.

  28. Differentiation • During development, differentiation is the process by which cells become specialized. In other words, cells become structurally and functionally different. • Different cell types express (make proteins from) different genes within the DNA sequence of the nucleus. (http://scienceblogs.com/clock/2006/12/from_two_cells_to_many_cell_di.php)

  29. How does differentiation occur? • During development of an embryo, both the internal environment of cells and the external environment of cells within the embryo differs. • This causes individual cells within the embryo to turn certain genes on and others off. • Genes become turned on when they are transcribed into mRNA for protein synthesis. • Different cell types produce certain proteins that are specific to the functioning of that cell type.

  30. T-R-I summarizationsDraw two 4-squares on one sheet of paper

  31. T-R-I summarizations

  32. T-R-I summarizations

  33. Written Response • Write a one paragraph response to the following question: • Explain the relationship between mitosis and growth that occurs during development • Remember: more depth = higher grade

  34. Four-Two-One • Test prep for next class • Differentiation

  35. Written Response • Write a one paragraph response to the following question: • Compare and contrast growth, differentiation, and senescencel • Remember: more depth = higher grade

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