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21 st Birthday Study

21 st Birthday Study. Angela Freeman. Overview of study…. Principal Investigator: Dr. Kerns Main goal: to study neural effects of extreme drinking in young adults Single occurrence of extreme drinking occurs on 21 st birthday Young adults may attempt 21 drinks/shots on bday. Continued….

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21 st Birthday Study

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  1. 21st Birthday Study Angela Freeman

  2. Overview of study… • Principal Investigator: Dr. Kerns • Main goal: to study neural effects of extreme drinking in young adults • Single occurrence of extreme drinking occurs on 21st birthday • Young adults may attempt 21 drinks/shots on bday

  3. Continued… • Does this drinking episode produce any cognitive changes? • Will be using both the functional MRI and structural MRI

  4. Testing after extreme drinking • fMRI=examining decreased brain activity in the hippocampus as well as the prefrontal cortex • While completing a long-term memory cognitive task • Structural MRI=studying the decreased brain volume of hippocampus/prefrontal cortex

  5. Overview of Subjects • Goal: 70 participants • Subjects: young adults who are turning 21 years old • Subjects must be celebrating/drinking on 21st birthday • Will participate in three separate interviews

  6. Screening • Must make sure participant is eligible • Initial participant screening form • Would complete screening form via phone • Since conducting a MRI scan must take safety precautions

  7. Continued… • Screened for… • Pacemaker /Mechanical Device • Body piercings • Braces-can distort data • Welding? • Claustrophobic?

  8. First Interview • Responsible for conducting first interview • Length: 1.5 to 2 hours • Many different interviews • Hangover Symptoms Scale • Lifetime Drinking History • Diagnostic Interview Schedule for DSM-IV

  9. Hangover Symptoms Scale • Hangover symptoms last 12 months • Ex. “In the past 12 months when you drank alcohol, how often did you feel more tired than usual the next morning?” • Answer options: • 1. Never • 2. Occasionally • 3. About half the time • 4. Most of the time • 5. Every time I drink alcohol

  10. Lifetime Drinking History • When first phase of drinking • Anymore phases of drinking? • Example: high school, or when first start college • To get an idea of drinking history

  11. Continued… • Start with beginning phase • Ask about life events • Ask if event was positive, negative, or neutral • How often would drink alcohol/how much? • % of beer, liquor, or wine • Drink alone/with others

  12. Diagnostic Interview • Very lengthy • Has different sections • Demographics, Generalized Anxiety Disorder, Depression, Nicotine Dependence • Longest interview • Mainly yes/no questions

  13. MRI training • Brain scans held at Brain Imaging Center • Had to become a Level One MR Personnel • Level 3 or 4 Personnel must accompany me • Would assist the graduate student with various tasks

  14. MRI Training • Training consisted of: • Receive tour of the facility • Location of emergency buttons and switches • Certification-safety training quiz

  15. Scan time! • Very important take all metal off!! • Scanner operator must take all metal off • Scanner=almost two hours • Cognitive tasks while in scanner • Show video first • Planet Earth

  16. First task • Imagery task • See 2 words at a time • Form a mental image • If a excellent image press with right index finger • If poor image press with right middle finger • After scan will ask about words saw in scanner

  17. Second task • N-Back Task • See a series of circles on screen • For every circle decide if it was in same spot three circles ago • Right index finger=same • Right middle finger=different • Measures working memory

  18. Example SAME

  19. After scan • Need to complete another cognitive task • Basically ask about words saw in scanner • Asked participants to form mental image • After this participant done with first scan!

  20. Interviews • 2nd interview • Ask about birthday celebration • What occurred/how much standard drinks consumed? • Data first 10 participants • Average number of standard drinks=13.2 • 80%=10 or more drinks • 20%=21 or more drinks (max = 28) • Activities participated in • Bar-hopping, dancing, did you embarrass yourself?, card games • Who celebrate with?

  21. Third Interview • 5 weeks after second scan • Final scan • Assess how much had to drink previous 5 weeks

  22. Goals of study • Recruit more participants • Goal=70 all together • Analyze brain activity/structure • Discover any changes in brain?

  23. THE END!!!!!

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