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Antipsychotic Therapy Quiz. 1. What is a limitation to the ‘Dopamine Hypothesis’ model explaining schizophrenia? It does not account for the cognitive deficits associated with schizophrenia It does not account for psychosis associated with amphetamine abuse
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1. What is a limitation to the ‘Dopamine Hypothesis’ model explaining schizophrenia? • It does not account for the cognitive deficits associated with schizophrenia • It does not account for psychosis associated with amphetamine abuse • It does not account for the strong association with tobacco and schizophrenia • It does not account for increased psychosis associated with L-DOPA
2. The antischizophrenic effect of most neuroleptic drug is associated with their binding to which of the following dopamine (D) receptors? • D1 • D2 • D3 • D4 • D5
True/False 3. Most common cause of relapse is due to non-adherence of antipsychotic therapy True 4. Most common cause of failure of treatment is inadequate dosage of antipsychotic drugs True
5. Which of the following conditions are not treated with neuroleptic drugs? A. Alcholic hallucinations B. Amphetamine pyschosis C. Tourette Syndrome D. Intractable hiccips E. All of the above are treated with neuroleptic drugs
7. Which extrapyramidal side effect appears most frequently after long term usage of antipsychotics? A. Acute dystonias B. Akathisia C. Parkinsoniansymptoms D. Tardivedyskinesia
8. Tardivedyskinesia after long-term antipsychotic administration is thought to be due to A. A decrease in dopamine synthesis B. Enhanced stimulation of D2 dopamine autoreceptors C. Up-regulation of striatal dopamine receptors D. Increased tolerance to antipsychotic agents E. None of the above