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MRI of the locus coeruleus and substantia nigra

MRI of the locus coeruleus and substantia nigra. Dr Timothy Rittman Academic Foundation Year 2. Locus coeruleus. Substantia nigra. Imaging of SN. Sasaki et al. Effect of MT and SPIR. Magnetisation transfer. Neuromelanin Macromolecules = short T2* Off resonance radiofrequency pulse

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MRI of the locus coeruleus and substantia nigra

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  1. MRI of the locus coeruleus and substantia nigra Dr Timothy Rittman Academic Foundation Year 2

  2. Locus coeruleus Substantia nigra

  3. Imaging of SN

  4. Sasaki et al

  5. Effect of MT and SPIR

  6. Magnetisation transfer • Neuromelanin • Macromolecules = short T2* • Off resonance radiofrequency pulse • Transfer of energy from macromolecules • water • ?iron • SPIR • presaturation pulse • hidden MT effect

  7. Method • T1 MRI • Repetition time 757ms • Echo time 9.1ms • Voxel size = 0.47x0.47x2.75mm3 • SPIR • 7 healthy volunteers • MT not possible due to SAR limits

  8. Results - Substantia nigra

  9. Results - Locus coeruleus

  10. Conclusion • The substantia nigra and locus coeruleus are visible using T1 weighted imaging with SPIR • Most likely due to an MT effect • Sequence is sensitive to neuromelanin • Specificity remains to be tested

  11. Thanks to… • Prof Auer • All in Academic Radiology • All at Sir Peter Mansfield Magnetic Resonance Centre • Prof Mahida and Prof Hawkey

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