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pRB Binds to the E2F Transcription Factor

pRB Binds to the E2F Transcription Factor. G1 Cyclin CDKs Phosphorylate pRB. Sites of RB Missense Mutations in Tumors. B. A. The A and B domain = pocket = where E2F binds. Tumorigenesis in RB Mutant Mice Requires E2F. Yamasaki et al, Nat. Gen. 18:360 (1998). Proliferation Signals.

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pRB Binds to the E2F Transcription Factor

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  1. pRB Binds to the E2F Transcription Factor

  2. G1 Cyclin CDKs Phosphorylate pRB

  3. Sites of RB Missense Mutations in Tumors B A The A and B domain = pocket = where E2F binds

  4. Tumorigenesis in RB Mutant Mice Requires E2F Yamasaki et al, Nat. Gen. 18:360 (1998)

  5. Proliferation Signals p16 Regulates pRB Phosphorylation

  6. p16 is a Human Tumor Suppressor

  7. Proliferation Signals The Canonical p16/pRB/E2F “Pathway”

  8. (p16) The RB Pathway in Human Cancer Sherr and McCormick, Cancer Cell ·2:103 (2002)

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