1 / 37

Self vs Non-self

Recognition of:. Self vs Non-self. Presence vs Absence. Harmless vs Dangerous. hematopoiesis. pluripotent. Recognition of:. Self vs Non-self. Presence vs Absence. Harmless vs Dangerous. What’s wrong with this fruit fly?.

lamis
Download Presentation

Self vs Non-self

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Recognition of: Self vs Non-self Presence vs Absence Harmless vs Dangerous

  2. hematopoiesis pluripotent

  3. Recognition of: Self vs Non-self Presence vs Absence Harmless vs Dangerous

  4. What’s wrong with this fruit fly? Missing toll or other members of the toll pathway

  5. Is it dangerous?

  6. Recognition of: Self vs Non-self Presence vs Absence Harmless vs Dangerous

  7. hematopoiesis pluripotent

  8. Involution of the thymus

  9. hematopoiesis pluripotent

  10. Another accident with chickens • 1956: Bruce Glick “accidentally” vaccinates bursectomized chickens • Finds they make poor antibody responses

  11. The lymphocyte

  12. Antigen receptors assembled by somatic recombination 2 Light chains (IgL) b, d a, g Heavy chain Light chain 2 Heavy chains (IgH) Variable domain Constant domain TCR or T Cell Receptor Ig or B cell receptor

  13. Antigen

  14. Germline DNA Recombination 3 1 2 1 2 3 3 1 3 Transcription –Splicing -Translation Transcription –Splicing -Translation Recombination 2 2 3 2 1 2 3 Protein: T Cell Receptor Germline DNA Generation of Diversity in Antigen Receptors Vn V3 V2 V1 D  JC T cell V D J C V J C Vn V3 V2 V1 JC

  15. Fig 8-8

  16. Recognition of: Self vs Non-self Presence vs Absence Harmless vs Dangerous How is self-tolerance maintained?

  17. Frank Macfarlane Burnet* Believed any correct theory must explain: • How antigen selects correct specificity • Why only a single specificity is produced • How self tolerance is maintained • Why second response to same antigen is so much larger than the first *1958 Nobel Prize

  18. Clonal Selection Theory • Each cell is a unique clone with its own specificity • If the cell encounters Ag in a premature state, it dies • The mature pool of cells represent those that did not encounter the Ag they are specific for during development • When mature cell encounters Ag it begins to divide (clonal expansion) = foreign antigen

  19. Recognition of: Self vs Non-self Presence vs Absence Harmless vs Dangerous

  20. Fig 8-8

  21. Mice & Cattle Mice & Primates Primates & Cattle

  22. Fig 12-5

More Related