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DNA Mutations: Substitution and Frameshift Explained

Understand single base changes and codon shift mutations in DNA with examples and explanations. Learn about the impact of point mutations on genetic information.

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DNA Mutations: Substitution and Frameshift Explained

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  1. BASE MUTATIONS

  2. POINT MUTATION Substitution - A change in a SINGLE BASE in DNA THE DOG BIT THE CA T THE DOG BIT THE CA R ACG AT CCC T DNA – mRNA – tRNA TAT – AUA – UAU ISO ACG AT CCC G DNA – mRNA – tRNA GAT – CUA – GAU LEU

  3. POINT MUTATION Substitution- a change in a SINGLE BASE of DNA. ACG TA CCC T ISO DNA – mRNA – tRNA TAT – AUA – UAU ACG TA CCC A DNA – mRNA – tRNA TAA – AUU – UAA ISO

  4. FRAMESHIFT MUTATION A single base is added (insertion) or deleted (deletion) resulting in a shift of codon groups. THE DO BIT THE CAT G THE DO G B I T T H E C A T ACG AT CCC T DNA – mRNA – tRNA TAT – AUA – UAU ISO ACG T A T C C C DNA – mRNA – tRNA ATC – UAG – AUC STOP

  5. FRAMESHIFT MUTATION A single base is added (insertion) or deleted (deletion) resulting in a shift of codon groups. ACG TA GCC T ISO TAT – AUA – UAU ACG TA T G C C ? TAG – AUC - UAG ISO

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