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Canary Courtship The Story of Neurogenesis

Canary Courtship The Story of Neurogenesis. with Susan Wehry, M.D. Images of Aging. Images of Aging. STOP AGING NOW!. AGE WELL NOW. The brain can’t make new cells, RIGHT?. WRONG. What’s new about being old?. Neuronal plasticity Variability Modifiability. Genesis…Neuro style.

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Canary Courtship The Story of Neurogenesis

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  1. Canary CourtshipThe Story of Neurogenesis with Susan Wehry, M.D.

  2. Images of Aging

  3. Images of Aging STOP AGING NOW! AGE WELL NOW

  4. The brain can’t make new cells, RIGHT? WRONG

  5. What’s new about being old? • Neuronal plasticity • Variability • Modifiability

  6. Genesis…Neuro style

  7. The Songbird Story • Fernando Nottenbohm • 1980’s, Rockefeller University • Song center  spring • Hippocampus  fall

  8. The Songbird Skeptics • Restricted throughout evolution • New neurons would disrupt • No primate neurogenesis

  9. The Primate Story • Elizabeth Gould • Bruce McEwen • Hippocampus • Tree shrew • Marmoset • Rhesus monkey • Neocortex

  10. The Human Story • Fred Gage • Cancer patients • Neurogenesis • human hippocampus

  11. Do they work? • Enriched environments  • heavier brains •  synapses •  branching •  learning Even in very old mice

  12. Neurogenesis • Stimulated by • Enriched environments • toys and friends • Participation in learning • Physical exercise

  13. Neurogenesis • Inhibited by • Isolation • Stress

  14. What About Us?

  15. The Aging Brain • Knowledge in transition • Tremendous variation • Within the brain • Between individuals

  16. Components Dendrites Cell body Synapse Axon

  17. Neurons 100,000,000,000 ONE HUNDRED BILLION

  18. Synapses 10,000s /neuron 104 X 1011 = 1,000,000,000,000,000

  19. ONE Quadrillion

  20. And we lose maybe 10,000/day

  21. The Brain responds • Neurogenesis • Synapses reorganize • Dendrites sprouting

  22. The Human Hippocampus • Main relay station • New memory • Long term storage • Discard

  23. The Human Hippocampus • London Taxi Drivers • Enlarged • Right activated routes • Dementia, Alzheimer’s type • Smaller volume

  24. The Aging Brain • Decrease in brain weight • Plasticity >  Neurons • Function • Less efficient • Slower rate • No change in total learning • Modifiable

  25. Successful Aging • MacArthur Foundation • Genetic factors < 50% • Education strongest predictor • Health • Physical/mental • Optimism/Self-efficacy • Social support

  26. Successful aging

  27. Barriers to successful aging As we age, our expectations change: • we demand less and less of our brains • we link our absentmindedness to age • we accept ageist stereotypes

  28. Remove the Barriers • Alter expectations • Develop a strategy

  29. Take Stock • Illness inventory • Health inventory • Stress inventory

  30. Change Behavior • Make a pledge • Identify goal • Visualize undertaking

  31. Change Behavior • Plan for success • Set up a routine • Engage a partner • Get started

  32. EXERCISE BODY BRAIN

  33. PRACTICE Remembering Thinking Problem-solving

  34. Strategies • Maintain health • Physical • Mental • Stay connected • Active life style • Nutrition • Enrich environment

  35. You heard it here! • Use it or lose it “That which is used develops, that which is not used, wastes away” (Hippocrates 460-337 B.C.)

  36. You heard it here! • Story of neurogenesis • Knowledge • aging human brain • successful aging • Strategies

  37. You heard it here! • Alter expectation • Remember mama • Stay connected

  38. To learn more or just to stay in touch Please visit my website www.susanwehrymd.com

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