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Development of markers in ANIMALS

ADNI-related initiatives in Europe : Pharma-Cog WP5 (E-ADNI). AIM : To develop new markers homologous in animal and humans sensitive to the effect of symptomatic and disease modifying drugs. Disease- modifying drugs. Development of markers in ANIMALS.

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Development of markers in ANIMALS

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  1. ADNI-relatedinitiatives in Europe: Pharma-Cog WP5 (E-ADNI) AIM: To develop new markers homologous in animal and humanssensitive to the effect of symptomatic and disease modifying drugs Disease- modifying drugs Development of markers in ANIMALS Development of markers in HUMANS Symptomatic drugs Development of markers in ANIMALS Development of markers in HUMANS

  2. Pharma-Cog Disease modifyingdrugssection WP5 WP6 75 MCI Ab42 pos. and 75 neg. Serial ass.t: 6 mos x 3 yrs ADNI cogn. tests ADNI struct MRI ADNI2 diffusion MRI, rest fMRI MR spectroscopy EEG & ERPs CSF & Blood Amyloid img (AZ ligand, others?) E-ADNI APP, APP/PS1, Tau, APP/Tau/PS2 mouse and lemur monkeys Serial ass.t: 3 mos x 2 yrs Homol. cogn. tests Homol. struct diff func MRI Homol. MR spectroscopy Homol. EEG & ERPs CSF & Blood Histology

  3. Pharma-Cog: partners Programs of peripheralbiomarkerdiscovery Takesactive part to design, statanalysis, etc.

  4. Pharma-Cog: timeschedule 2010 2011 2012 2013 2014 Literature review Data coll. prot.s IRB submissions Qualification Patient enrollment QC & QC enforcement Patient follow-up Data analysis

  5. Pharma-Cog: funding source IMI – Innovative Medicines Initiative: European Commission’s research scheme aimed to foster drug development by promoting academia-pharma (50-50) large joint research projects. 15 Funded so far: Alzheimer’s, Cancer, Diabetes (2), Pain, Depression & schizophrenia, Respiratory dis. (2), Basic pharmacology (7)

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