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RED BLOOD CELLS RBCs

ILOs:The student should be able to:Define ErythropoiesisRecognize normal RBCs and their parametersRecognize RBCs abnormalitiesDefine anaemias. Identify morphological types of anaemiasSelect appropriate investigation(s) in each anaemia (disease)?Integrate knowledge learnt in the course with o

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RED BLOOD CELLS RBCs

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    4. ?Definition: It is formation, proliferation, maturation and release of the RBCs into the circulation. This takes place in the BM.

    5. Proerythroblast Early normoblast Intermediate normoblast Late normoblast Reticulocytes Mature RBCs

    6. Biconcave disc shaped 7.2 µm in diameter Seen normally with central hallow Life span: 120 days Precursors are called normoblasts (or nucleated RBCs). Normally, they do not appear in the circulation Reticulocytes ( polychromatic RBCs) normally are 0.5-2.5% of RBCs

    17. ?Definition: It is a decrease in Hb concentration, RBC count and/or PCV below the average normal for age and sex

    20. In iron def., must Ferritin be combined with SFe and TIBC? Yes, because: 1st to decrease in Fe def. Acute stress ? ?sFe (-ve acute phase reactant)? Intake of single high Fe meal/mineral pills ??sFe Coexisting ch. Inflamation ? ?TIBC Marked ?sFerritin rules out Fe def.

    21. ?Definition: Genetically determined familial defect in globin chain synthesis ? imbalance in globin chain production ? abnormal erythropoiesis + hemolytic anemia

    22. ?Thalassemia major: - Marked degree of microcytic hypochromic anemia - Increased serum iron, ferritin. - PB : normoblastemia, target cells, anisopoikilocytosis, reticulocytosis - Hb electrophoresis: Hb F in ß thalassemia Hb H in a thalassemia

    27. ?Definition: It is anemia due to increased rate of RBCs destruction.

    33. To reach proper diagnosis, 3 basic questions should be answered: Is the patient anemic ? A: Hb level 2. What is the type of anemia? A: RBCs parameters: MCV; MCH 3. What is the cause of anemia? A: CBC ; cell morphology; reticulocytic count; other confirmatory tests

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    40. Formulate a laboratory diagnostic plan for: Microcytic hypochromic anaemia

    46. THANK YOU

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