1 / 6

Promoters in Eukaryotic DNA

Promoters in Eukaryotic DNA. By: Kim Brown. TATA Box – 25-35 base pairs upstream from the start site A change in the sequence of the TATA box can drastically change the transcription rate by RNA polymerase II .

lara
Download Presentation

Promoters in Eukaryotic DNA

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Promoters in Eukaryotic DNA By: Kim Brown

  2. TATA Box – 25-35 base pairs upstream from the start site • A change in the sequence of the TATA box can drastically change the transcription rate by RNA polymerase II

  3. In most cases a change between the TATA box and the start box will not significantly affect the rate of transcription.

  4. Initiator- cytosine (C) at the –1 position and adenine (A) at the transcription start site (+1) • The nucleotide sequence immediately surrounding the start site determines the strength of such promoters • (5`) Y-Y-A(+1)-N-T/A-Y-Y-Y (3`)

  5. CpG Islands- CG rich stretch of 20-50 nucleotides. Approximately 100 base pairs upstream from start site • The dinucleotide CG is underrepresented in Vertebrae DNA, and the presence of CG rich regions just upstream from start site is a nonrandom distribution

  6. ?? Questions ??

More Related