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WT1 and Wilms ’ Tumor

WT1 and Wilms ’ Tumor. Sarah DeHart. DNA-binding transcription factor Protein carries 4 C-terminal zinc fingers. 36 different isoforms based on splicing Specific isoforms can have different functions. WT1 Expression in Development. WT1 Pathway. WT1 Role in EMT/MET.

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WT1 and Wilms ’ Tumor

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  1. WT1 and Wilms’ Tumor Sarah DeHart

  2. DNA-binding transcription factor Protein carries 4 C-terminal zinc fingers 36 different isoforms based on splicing Specific isoforms can have different functions

  3. WT1 Expression in Development

  4. WT1 Pathway

  5. WT1 Role in EMT/MET

  6. WT1 inheritance patters

  7. What’s wrong here?

  8. References • Chau, Y.-Y., & Hastie, N. D. (2012). The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis. Trends in Genetics, 28(10), 515–524. Retrieved from http://www.sciencedirect.com/science/article/pii/S0168952512000686 • Haber, D. A., Buckler, A. J., Glaser, T., Call, K. M., Pelletier, J., Sohn, R. L., Douglass, E. C., et al. (1990). An Internal Deletion within an 11p13 Zinc Finger Gene Contributes to the Development of Wilms’ Tumor. Cell, 61, 1257–1269. Retrieved from http://ac.els-cdn.com/009286749090690G/1-s2.0-009286749090690G-main.pdf?_tid=30525422-8c19-11e2-af4f-00000aab0f26&acdnat=1363205238_bea33c28750fe3929effc614e36c2d31 • Gessler, M. (1991). WT1 (Wilms’ tumor suppressor gene). Retrieved from http://atlasgeneticsoncology.org/Genes/WT1ID78.html • Hohenstein, P., & Hastie, N. D. (2006). The many facets of the Wilms’ tumour gene, WT1. Human Molecular Genetics,15(2), R196–R201. doi:10.1093/hmg/ddl196 • Miller-Hodges, E., & Hohenstein, P. (2011). WT1 in disease: shifting the epithelial–mesenchymal balance. Journal of Pathology, 226, 229–240. doi:10.1002/path.2977 • Pritchard-Jones, K., Flemming, S., Hastie, N., Bickmore, W., Porteous, D., Godsen, C., Bard, J., et al. (1990). The candidate Wilms’ tumour gene involved in genitourinary development. Nature, 346, 194–197. Retrieved from http://www.nature.com.libproxy.lib.unc.edu/nature/journal/v346/n6280/pdf/346194a0.pdf • Stoll, R., Lee, B. M., Debler, E. W., Laity, J. H., Wilson, I. A., Dyson, H. J., & Wright, P. E. (2007). Structure of the wilms tumor suppressor zinc finger domain bound to DNA. Journal of Molecular Biology, 372, 1227. Retrieved from http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=62809 • Tiller, G. E. (2011). Wilms Tumor 1; WT1. Retrieved from http://omim.org/entry/194070 • WT1. (2009). Retrieved from http://ghr.nlm.nih.gov/gene/WT1 • Pictures • http://www.projekt-koni.de/77.html?&L=1 • http://radiology.rsna.org/content/early/2012/11/20/radiol.12120670/F1.expansion.html • http://practicalimaging.blogspot.com/2012/07/new-case-of-week.html • http://www.sciencedirect.com/science/article/pii/S0031395505705307

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