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The Use of Home Electronic Blood Pressure Monitoring (HeBPM) in Renal Transplant Recipients. Daniel R. Migliozzi, PharmD Clinical Pharmacist, Renal Transplantation Rhode Island Hospital . Disclosure. Daniel Migliozzi: nothing to disclose . Pharmacist Objectives.
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The Use of Home Electronic Blood Pressure Monitoring (HeBPM) in Renal Transplant Recipients Daniel R. Migliozzi, PharmD Clinical Pharmacist, Renal Transplantation Rhode Island Hospital
Disclosure • Daniel Migliozzi: nothing to disclose
Pharmacist Objectives • Discuss the clinical impact of hypertension on transplant related outcomes • Associate the impact of HeBPM on improved blood pressure management • Identify current progress in the HeBPM program at RIH and discuss a notable patient case
Technician Objectives • Identify methods for pharmacy technician involvement in a HeBPM program • Discuss the role of the pharmacy technician for improving patient adherence with HeBPM
Post-transplant Hypertension • 70-90% of renal transplant patients:1-3 • Have arterial hypertension • Require antihypertensive therapy • Few renal transplant recipients achieve optimal BP targets one year after transplant4,5 • Miller LW. Cardiovascular toxicity of immunosuppressive agents. Am J Transplant 2002; 2: 807. • Midvtvedt K, Hartmann A. Hypertension after kidney transplantation: are treatment guidelines emerging? Nephrol Dial Transplant 2002; 17: 1166. • Schwenger V, Zeier M, Ritz E. Hypertension after renal transplantation. Ann Transplant 2001; 6: 25. • Paoletti E et al. Transplantation 2009; 87: 1864-1869 • Mange KC et al. JAMA 2000; 283: 633.
Blood Pressure and Graft Survival • An in SBP by 5 mm Hg1 • Increases the risk of graft loss • Decreases patient survival • A in SBP even in patients with HTN for years after kidney transplant is associated with improved patient and graft survival2 • Premasathian NC et al. J Hum Hypertension 2004; 18: 871-877 • OpelzG et al. American Journal Transplant. 2005; 5: 2725-2731
Methods for Blood Pressure Monitoring • Office (OBPM) • Home (HBPM) • Self measurement • Hand written logs • Electronic record (HeBPM) • 24 hour ambulatory measurement (ABPM)
Benefits of HeBPM Technology • Minimizes reporting bias • Assessment of BP variability – graphs • Assessment of evening blood pressure • Multiple measurements and real time data • Provides preliminary assessment of adherence • Clinical decision support tool - averages LovibondK et al. Lancet 2011; 378: 1219-1230
HeBPM and MTM • Hypertension management protocols in use by community pharmacies and primary care clinics • Blood pressure data obtained from • Home monitoring (computer uploads) • Automated blood pressure kiosk Zillich AJ et al. J Gen Intern Med 2005; 20: 1091-1096
Benefits of MTM in Renal Transplantation • Transplant patients require multiple medications • complexity of medication regimen • risk for non-adherence = uncontrolled BP • the potential for medication-related problems (MRPS) • Renal transplant patients with MRPs are more likely to have 30 day readmissions • (5% vs. 16%, p = 0.018)1 Taber DJ et al. Pharmacotherapy 2012; 32: 1053–1060
The HeBPM Program at RIH • Total number of patients: 100 • Enrollment • All new transplant recipients • Patients well out from transplant • Close monitoring required • Referred by MD • Program focused on the following elements • Improving blood pressure control • Medication adherence • Reducing medication related problems • Patient involvement in their own care
Role of the Pharmacy Technician • Completion of enrollment process • Instruction on kiosk operation • Assist with promoting adherence via follow-up telephone calls • Coordinate data to other providers involved in patients care
Patient Case • HPI: 74-year-old M s/p living donor renal transplant 7-1/2 years ago. Post-transplant course unremarkable but noted to have elevated BP during office visit. Enrolled in HeBPM program on: 10/23/2012. • BP meds: • Lisinopril 20 mg twice daily • Metoprolol 50 mg twice daily
Home Blood Pressure Readings
RIH HeBPM Summary • Useful tool to supplementOBPM and improve HTN management • Program fosters patient involvement • MTM piece assists w/ resolving MRPs & adherence • Technology adds convenience for patient & provider • Programs like this provide opportunity and career growth for pharmacy technicians • Area for future research