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Virus/Host Interactions

Detrimental SEVI promotes virion interaction with cells WFDC1 enhances HIV entry Chemokines recruit CD4+ target cells to the mucosa Immunostimulatory factors e.g. defensins, type 1 IFNs and TNF a drive immune activation and enhance HIV replication. Vaccines and microbicides.

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Virus/Host Interactions

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  1. Detrimental • SEVI promotes virion • interaction with cells • WFDC1 enhances HIV entry • Chemokines recruit • CD4+ target cells to the mucosa • Immunostimulatory factors e.g. • defensins, type 1 IFNs and TNFa • drive immune activation • and enhance HIV replication Vaccines and microbicides • Beneficial • Antiviral activity of • defensins, • WAPs (SLPI/elafin), • and type 1 IFN • Anti-inflammatory activity of • WAPs (SLPI/elafin/WFDC1) Virus/Host Interactions HIV transmission and establishment of infection Blockade or elimination of infection

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