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  1. Archived File The file below has been archived for historical reference purposes only. The content and links are no longer maintained and may be outdated. See the OER Public Archive Home Page for more details about archived files.

  2. PEER REVIEW ADVISORY COMMITTEE Update on New CSR Realignments Joy Gibson, Rene Etcheberrigaray, and Don Schneider June 8, 2009 National Institutes of HealthU.S. Department of Health and Human Services

  3. Continuous evolution/alignment of study sections is necessary • Science changes • CSR is committed to assessment • Study section size matters – too small/too large [fewer than 50 applications]

  4. Bioengineering has three small study sections (after removing SBIRs) • BDMA (Biodata Management and Analysis) 35-50 applications • MABS (Modeling and Analysis of Biological Systems) 35-65 applications • MI (Microscopic Imaging) 20-60 applications (including PAR-07-344, research and developments in computational science and technology) [SBIR receipt month/two after R01s]

  5. Bioengineering Working Group met Feb 2009 ROSTER • Russ Altman, MD, PhD (Stanford University) • Michael Gilson, MD, PhD (University of Maryland) • Larry McIntire (Georgia Tech) • Kevan Shokat, PhD (University of California San Francisco) • Peter Sorger, PhD (Massachusetts Institute of Technology) • Phoebe Stewart, PhD (Vanderbilt University) • Shankar Subramaniam, PhD (University of California San Diego) • NIH: James Deatherage, PhD (NIGMS); Gregory Farber, PhD (NCRR); Yantian Zhang, PhD (NIBIB); George Chacko, PhD (CSR); Don Schneider, PhD (CSR)

  6. Bioengineering Working Group recommended changes • Expand guidelines and rename MI, e.g., Microscopic Imaging and Spectroscopy [50 applications] • Merge Biodata Management & Analysis and the Software Maintenance special emphasis panel (SEP) [60-80 applications] • Adjust Modeling & Analysis of Biological Systems guidelines (including some machine learning and discrete modeling applications from BDMA) [45-70 applications]

  7. Digestive Science study sections have grown slowly • GCMB (Gastrointestinal Cell and Molecular Biology) 40 applications • GMPB (Gastrointestinal Mucosal Pathobiology) 45 applications • HBPP (Hepatobiliary Pathophysiology) 70 applications • CIGP (Clinical and Integrative Gastrointestinal Pathobiology) 50 applications

  8. Digestive Sciences Working Group met March 2009 ROSTER • Fayez Ghishan, MD (University of Arizona) • Fred Gorelick, MD (Yale University) • Juanita Merchant, PhD, MD (University of Michigan) • Reza Shaker, MD (Medical College of Wisconsin) • William Stenson, MD (Washington University, St. Louis) • Mary Vore, PhD (University of Kentucky) • Allan Wolkoff, MD (Albert Einstein College of Medicine) • Vincent Yang, PhD, MD (Emory University) •  NIH: Jill Carrington, PhD (NIDDK); Edward Doo, PhD, MD (NIDDK); Mushtaq Khan, DVM, PhD (CSR); Don Schneider, PhD (CSR)

  9. Digestive Science Working Group agreed to realign • Redistribute Gastrointestinal Cell & Molecular Biology applications into the other three study sections • Merge the majority (20-25 applications) with Clinical & Integrative Gastrointestinal Pathobiology, and rename as Clinical, Integrative and Molecular Gastroenterology (CIMG) [70-75 applications] • Move immunology/microbiology applications (5-10) to Gastrointestinal Mucosal Pathobiology [50-60 applications] • Move liver applications (5-10) to Hepatobiliary Pathophysiology [75-80 applications]

  10. Similar issues are developing in other areas • Decreasing workload in Erythrocyte and Leukocyte Biology (ELB) • Declining workload in Electrical Signaling, Ion Transport, and Arrhythmias (ESTA) • Biological Rhythms and Sleep (BRS) remains small

  11. # Apps. R01 WBC

  12. The Problem: decreasing workload in ELB with striking decrease in leukocyte applications The Process: • Engage scientists representing the Hematology community in discussion over the problem and potential solutions • Present the situation and outcome of community discussions to involved IC staff • Convene working group • Consider new workload demands 2009-2010 • Present plan to PRAC

  13. Number of Applications reviewed in ESTA since inception Total No. of Applications Council

  14. The Electrical Signaling, Ion Transport, & Arrhythmias Problem: Declining workload over 2 years The Process: • Engage representatives of the involved academic and clinical communities in discussion over causes and solutions • Involve NHLBI staff in evaluating options • Set up working group for final evaluation • Consider new workload demands 2009-2010 • Present plan to PRAC

  15. Biological Rhythms &Sleep – Issues • BRS has remained a consistently small study section, reviewing 25-30 applications per cycle • BRS serves two specific research communities Circadian/Biological Rhythms Sleep • BRS, while broad in terms of experimental approaches, may be too narrow by overarching topic • Concentration of topics limits cross-fertilization with other research areas • Competition within a narrow area may limit success rate

  16. BRS – Applications per Review Cycle

  17. BRS Program Input/Recommendations April–May 2009 Participants: • Michael Twery, NHLBI; Merrill Mitler, NINDS; Aleksandra Vicentic, NIMH; Laurie Tompkins, NIGMS • Christine Melchior, Michael Selmanoff, René Etcheberrigaray: CSR Recommendations: • Distribute applications into existing Study Section with related topics; e.g., LAM for role of Biological Rhythms and Sleep (BRS) in learning and memory, NNB for applications studying the interplay between circadian and homeostatic processes • Add specific BRS expertise to recipient study sections (to LAM, NNB and others): 2-3 chartered members • Merge BRS with another study section (e.g., PMDA) – option not favored my majority • Convene a formal Working Group involving the communities affected

  18. PRAC advice sought Bioengineering Sciences and Technologies • Expand MI as Microscopic Imaging & Spectroscopy • Incorporate software maintenance applications into Biodata Management & Analysis and move some applications to Modeling & Analysis of Biological Systems Digestive, Kidney, & Urological Systems • Move majority of Gastrointestinal Cell & Molecular Biology to Clincal & Integrative Gastrointestinal Pathobiology to form Clinical, Integrative & Molecular Gastroenterology (revitalize both core elements) • Move immunology/microbiology applications to Gastrointestinal Mucosal Pathobiology • Move liver applications to Hepatobiliary Pathophysiology

  19. The End

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