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300. 250. 200. [ ] NO x - µmol/l. 150. 100. 50. 0. 5 ’. 10 ’. 15 ’. Time (minutes). *. [ ] NO x - µmol/l. HPMC. HPMC + GSNO 1mM. A. B.

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  1. 300 250 200 [ ] NOx- µmol/l 150 100 50 0 5’ 10’ 15’ Time (minutes) * [ ] NOx- µmol/l HPMC HPMC + GSNO 1mM A B Supplementary Figure 1. Capacity of exogenous GSNO in achieving intraocular sites. A. NOx- concentrations measured by NOA chemiluminescence (Nitric Oxide Analyser) method from aqueous humour after 60 minutes of eye drop (GSNO 1mM) instillation at 15’, 30’, 45’ and 60’; p=0.003. B. Kinetics of the GSNO absorption in vitreous after 5’, 10’ and 15’ of instillation of GSNO eye drop evaluated by NOA chemiluminescence. The curve shows the concentration of NOx- (µmol/l). It was observed an increase in NOx- levels on aqueous humor and vitreous after topical administration of GSNO demonstrating that GSNO is able to cross the ocular barriers. These observations show that NOx- is rapidly detected in anterior chamber (aqueous humour) and also inside the vitreous with a rapidly decrease in its concentration

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