University of Ottawa Brain and Mind Research Institute

1. OHRI IRSO University of Ottawa Brain and Mind Research Institute (uOttawa BMRI) A University of Ottawa Research Institute in Partnership with the University of Ottawa Institute of Mental Health Research and the Ottawa Health Research Institute

2. Outline of Presentation • The Strategy • The Tactic • The Action Plan • Comments, Questions and Answers

3. The Strategy: the Context • uOttawa • Vision 2010’s Strategic Areas of Development • A move from generic growth to specific growth: “research intensive university” • uOttawa Faculty of Medicine • A desire to focus in specific areas of health education, research or of leadership • A desire to move from “Strong to Strongest”

4. The Strategy: The Context • Choose a focus from the perspective of society’s burden of illness • Review uOttawa’s research strength

5. The Strategy: the Burden of Illness/Mortality Rank and Percent for High Income Countries (WHO 2002) • Coronary heart disease 17.1% • Stroke and other cerebrovascular diseases 9.8% • Trachea, bronchus, lung cancers 5.8% • Lower respiratory infections 4.3% • Chronic obstructive pulmonary disease 3.9% • Colon and rectum cancers 3.3% • Alzheimer and other dementias 2.7% • Diabetes mellitus 2.7% • Breast cancer 1.9% • Stomach cancer 1.8%

6. The Strategy: the Burden of Illness/Disability (2002) Estimated DALY* for Non-Communicable Diseases in Canada (2002) • Neurological and psychiatric (+stroke) 4209 • Malignant neoplasms 1859 • Cardiovascular (-stroke) 1090 • Sense organ 600 • Respiratory 637 • Musculoskeletal 536 • Diabetes 417 • Digestive 337 • Endocrine 161 • Genitourinary 117 * DALY: Disability Adjusted Life Years per 100,000 Population (WHO 2002)

7. The Strategy: the Burden of Illness/Disability (2030) Ten Leading Causes of DALY for High Income Countries by 2030* • Unipolar depressive disorders 9.8 • Ischaemic heart disease 5.9 • Alzheimer and other dementias 5.8 • Alcohol use disorders 4.7 • Diabetes mellitus 4.5 • Cerebrovascular disease 4.5 • Hearing loss, adult onset 4.1 • Trachea, bronchus, lung cancers 3.0 • Osteoarthritis 2.9 • COPD 2.5 *Rank and total percent DALY (Mathers CD, Loncar D PLoS Med 2006)

8. The Strategy: the Increasing Burden of Illness • Mortality • 2nd place: Stroke and other cerebrovascular diseases • 7th place: Alzheimer and other dementias • Disability: • Clear 1st place: Psychiatric andNeurological (+stroke) Is from “Brain-Related Illnesses”

9. The Strategy: uOttawa’s Research Strength is in many areas of Brain-Related Illnesses • Ottawa Tops in Canada for Neurosciences Citations* • Average of 9.33 citations per paper (*Science watch, Sept/Oct 2005) • Ottawa Home to: • The Canadian Stroke Network, The Canadian Stem Cell Network • Ottawa a leading partner in the Heart and Stroke Society of Ontario’s Center for Stroke Recovery

10. The Strategy: uOttawa’s Strong Basic Brain-Related Illnesses Research • Faculty of Medicine • Depts of CMM, BMI &ECM • Institute for Systems Biology • Centre for Neural dynamics, Ottawa Institute for Systems Biology, Centre for Stroke Recovery, Centre for Neuromuscular Disease • Ottawa Health Research Institute (OHRI) • Neuroscience Program • University of Ottawa Institute for Mental Health Research (uO IMHR) • Mood disorders, Stress & Anxiety • Children's Hospital of Eastern Ontario Research Institute (CHEO RI) • Biomedicine/neurosciences, Apoptosis/neuronal • uOttawa: School of Psychology, Faculty of Health Sciences, Faculty of Science (Depts of Physics and Math) • uO partners: NRC

11. The Strategy: uOttawa’s Evolving Clinical Brain-Related Illnesses Research • OHRI • Parkinson’s, MS, Stroke… • Eating Disorders, Psychosis, Psychosomatics… • uO IMHR • Depression, Stress & Anxiety, Schizophrenia, Youth, Forensic • CHEORI • ADHD, Depression, Eating Disorders… • EBRI (Élisabeth Bruyère Research Institute) • Faculty of Medicine Departments of Medicine (Neurology, Rehabilitation), Psychiatry, Paediatrics, Family Medicine (Geriatrics) • uOttawa Faculty of Social Sciences (Psychology)

12. The Strategy A focus and leading edge in research in brain-related illnesses

13. The Tactic: Opportunities in Brain-Related Illnesses Research • From the clinical realities of Brain-Related Illnesses: a common organ dysfunction with high clinical co-morbidities • e.g. stroke-memory-depression;. Parkinson’s-anxiety-psychosis • For integration from the fragmentation • Basic research with basic research; clinical research with clinical research • For translational links from translational gaps • Basic-Human-Clinical-Service organization-… • From funding contexts • CIHR, Illness-based agencies, Canadian Mental Health Commission • From an advancement perspective • From Ottawa’s eagerness for “Big Visions” • From a new Dean’s opportunities

14. The Strategy and Tactic A focus and leading edge in research in brain-related illnesses through the creation of a uO Brain & Mind Research Institute

15. uO Brain & Mind Research Institute Clinical Research Basic Research Clinical Service

16. Macro Policy Population Service Clinical Translation Lifespan Organ Cellular Molecular Genomic Micro

17. Action Plans for the uO Brain & Mind Research Institute • Integrative level • Structural level • Academic organizational changes • Governance structure • Funding level • Investment in positions • Investment in operations • Coordinated advancement • Facility level • Core facilities • Space

18. Action Plan: Integration of Research Activities • Integration of Basic Research of the Faculty of Medicine: • Basic Science Depts of the Faculty of Medicine (BMI, ECM, CMM) • Basic Research OHRI • Basic Research uO IMHR • Integration of Clinical Research of the Faculty of Medicine: • Clinical Depts (Medicine, Psychiatry, Family Medicine, Surgery) • Clinical Research OHRI • Clinical Research uO IMHR • Integration of Basic and Clinical Research of the Faculty of Medicine • Integration of Research between Faculties (Medicine, Health Sciences, Social Sciences, Science)

19. Action Plan: Integration of Research Activities • Initial Potential Strategic Research Clusters • Neurobiology and Signaling • Brain related diseases • (Stroke, Parkinson's, MS etc.) • Cognitive impairment and disease • Therapies and prevention • Community and disease • Support scientific events • Support Scientific projects

20. Action Plan: Integration of Training Activities • Existing Programs • Neuroscience graduate program • Psychology graduate program • Clinician Scientist training program • Residency training programs • New Programs • MD/PhD Program • Interdisciplinary programs supported by basic, clinical and behavioral science departments • E.g. Clinical Neuroscience Ph.D., Cognitive Biology Ph.D.

21. Action Plan: Create an Organizational Structure Ownership Model Board Director uO Brain and Mind Research Institute Community Advocacy and Fundraising Group Research Advisory Committee Management Committee Programs & Scientist Faculty

22. Action Plan: Create a Leadership Capacity • Scientific Director • Responsible for establishing uOBMri Business and Scientific Plans and developing an integrated research model • Leads Recruitment and has direct scientific responsibility for uOBMri Faculty • Reports to Ownership comprised of participating Faculties and Research Institutes • Leadership support at the Basic and Clinical Departmental levels

23. Action Plan: Initial Investment in Existing Positions (Faculty of Medicine) Over 50 positions currently committed to Basic and Clinical Neuroscience and Mental Health Research • Basic Science Departments (Faculty of Medicine) • Up to 15 current neuroscience positions • Commitment of 4-5 new recruitments for Center for Stroke Recovery • OHRI • Up to 14 current basic neuroscience positions • IMHR • 8 Current core research • Clinical Departments (Faculty of Medicine) • Assumption of long term responsibility for 2-3 CSR positions • Investments from existing stipend pools into protected research time • At least 11 positions at present

24. Action Plan: Investment in Additional Positions (for Faculty of Medicine) • University • Creation of 5-7 new basic science positions and provisions for 3 research “star” positions • 3 CRC Chairs • Clinical Departments • Negotiations with AFP for increased and dedicated support of relevant research time • University, Ottawa Hospital, Royal Ottawa Hospital and Faculty of Medicine • Create 15-20 new positions through a $50M capital campaign to grow the uOBMri endowment from $5M to $55M

25. Action Plan: Investment of Existing Financial Resources • Faculty of Medicine • $2M endowment for Neurosciences • Heart and Stroke Centre for Stroke Recovery • ~$9million in support of 7 new scientific positions • OHRI • $3.3M endowment inherited from the Neuroscience Research Institute • IMHR • Provision of space and resources for basic and clinical research in mental health • University • Up to $8M in support of infrastructure (matching required) • All partners committed to Institute operational and administrative support

26. Action Plan: Facilities Development • Strategic Core Facility support for uOBMri through aligned CFI initiatives • A facility plan that brings together and links researchers across the sites • Potential Models: • Development of a Basic Neuroscience node at Health Sciences Campus partnered with Clinical Node at Civic, Mental Health Node at Royal and Behavioral Node on Main uO Campus (phase I?) • Development of Basic and Clinical Neuroscience Hub at Civic site with Mental Health and Behavioral Spokes at Royal and Main uO Campus (phase II?) • Development of combined basic, clinical, mental health and behavioral Hub on Carling Ave, with spokes extending to other sites for interactive activities. (phase II?) • 4) Others?

27. Action Plan: Visibility and Advancement • uOBMri to be branded as a uOttawa research institute in partnership with OHRI and uOIMHR • Advancement coordinated through a partnership between uOttawa, uOttawa Advancement Office, The Ottawa Hospital Foundation and the Royal Ottawa Health Care Group Foundation

28. Summary: the uOttawa Brain & Mind Research Institute • A strategy addressing a large burden of illness and based on our research strengths • A tactic of rationalization and coordination of regional academic activities in neuroscience, mental health and behavioral science • A tactic to enhance translational capacities between research, education and clinical care • An enhancement of research capacity through partnerships • An enhancement of advancement capacity through partnerships • An enhancement of branding and visibility for Ottawa

29. Comments & Questions?