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Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms

Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms. Corey Harada Advisor: Eleazar Eskin. Statement of Problem. Single Nucleotide Polymorphism (SNP) Mutation of a single nucleotide in a strand of DNA.

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Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms

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  1. Analysis of Phenotypic Variations in the Mouse Genome Caused by Single Nucleotide Polymorphisms Corey Harada Advisor: Eleazar Eskin

  2. Statement of Problem • Single Nucleotide Polymorphism (SNP) • Mutation of a single nucleotide in a strand of DNA. • Important in pharmaceuticals; affect how things respond to disease. • ~8.27 million SNPs found in classical mouse strains. • We know the locations of the SNPs on the mouse genome, but not what they do.

  3. Goals • Associate SNPs with phenotypic differences in mice. • SNPs in protein coding regions, noncoding regions, or intergenic region. • Develop new algorithms to accomplish the above goal • Difference in scale: previously, only ~140,000 SNPs had been mapped.

  4. Methodology • Organize the SNP data into an online database. • Use Ruby on Rails with MySQL database to construct webserver. • Assisted by graduate student Emrah Kostem.

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