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Physiology of Alcohol & Poisons

Chapter 9. Physiology of Alcohol & Poisons. Poisons. = chemicals that can harm the body if ingested, absorbed, or inhaled in sufficiently high concentrations Can detect and measure small amounts in human tissue. History of Toxicology. Early 1700s – used chemistry to detect poisons

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Physiology of Alcohol & Poisons

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  1. Chapter 9 Physiology of Alcohol & Poisons

  2. Poisons • = chemicals that can harm the body if ingested, absorbed, or inhaled in sufficiently high concentrations • Can detect and measure small amounts in human tissue

  3. History of Toxicology • Early 1700s – used chemistry to detect poisons • Dutch chemist, Hermann Boerhaave – arsenic has distinct odor when heated, but ineffective method in body • Others developed techniques to measure poisons in body • Early 19th century – new scientific discipline

  4. France, 1840 – 1st use in legal case – LaFarge murder trial • Marie accused of killing husband, Charles, with rat poison (arsenic) • English chemist, James Marsh – test to detect arsenic • Found traces of arsenic in food, but not body

  5. Orfila retested exhumed body • Found traces of arsenic in body, but not surrounding soil • So, not absorbed by body after burial • Marie LaFarge convicted of murder

  6. Forensic Toxicologist • Concerned with legal and medical aspects of alcohol, drugs, poisons, and toxins in bodily fluids • Often works with pathologist • Analyzes evidence to determine if alcohol or drugs contributed to crime • Presents expert testimony

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