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Laboratory Animal Science

University of Dublin, Trinity College. Laboratory Animal Science. Peter Nowlan. History. Agenda. Advances in Science and in animal experimentation through the ages The law Experimental Design Animal House design.

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Laboratory Animal Science

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  1. University of Dublin, Trinity College Laboratory Animal Science Peter Nowlan History

  2. Agenda • Advances in Science and in animal experimentation through the ages • The law • Experimental Design • Animal House design

  3. SI /17 /94 European Communities (Amendment of Cruelty to Animals Act 1876) Regulations 1994 (12) Persons who carry out experiments or take part in them and persons who take care of animals used for experiments, including duties of a supervisory nature, shall have appropriate education and training. In particular, persons carrying out or supervising the conduct of experiments shall have received instruction in a scientific discipline relevant to the experimental work being undertaken and be capable of handling and taking care of laboratory animals; they shall also have satisfied the Minister that they have attained a level of training sufficient for carrying out their tasks.

  4. Scientific advances • 500 BC Alcmaeon of Crotona (optic nerve function) • 464 BC Hippocrates • ( oesophageal function) • 384 Aristotle • 120 AD Galen (humors )

  5. Scientific advances • 500 BC Alcmaeon of Crotona (optic nerve function) • 464 BC Hippocrates • ( oesophageal function) • 384 Aristotle • 120 AD Galen (humors )

  6. Scientific advances • 500 BC Alcmaeon of Crotona (optic nerve function) • 464 BC Hippocrates • ( oesophageal function) • 384 Aristotle • 120 AD Galen (humors )

  7. Scientific advances • 500 BC Alcmaeon of Crotona • 350 BC Hippocrates • 384 Aristotle • 120 AD Galen Humors Barbary Ape

  8. GALEN’S HUMOURS Sanguine Phlegmatic Melencholic Choleric

  9. Scientific advances • Middle Ages • Little scientific advances. Church dominance Benedict Augustine

  10. Scientific advances • The Black Death pasturella pestis • Thomas Aquinas (1225-1274) broke the impasse between faith and science

  11. Scientific advances • The Black Death pasturella pestis • Thomas Aquinas (1225-1274) broke the impasse between faith and science

  12. Scientific advances • Thomas Aquinas (1225-1274) broke the impasse between faith and science • Printing press 1450

  13. Scientific advances • Rennasance late 14th centurary • Printing Gutenburg 1450 AD

  14. Scientific advances which depended on use of animals • 1800 • LISTER (1840) Carbolic Acid • SEMMELWEIS (1840) Child Birth Fever • PASTEUR (1857) Vaccines • KOCH (1900) Disease Tranmission

  15. Scientific advances which depended on use of animals • 1800 • LISTER (1840) Carbolic Acid • SEMMELWEIS (1840) Child Birth Fever • PASTEUR (1857) Vaccines • KOCH (1900) Disease Tranmission

  16. Scientific advances which depended on use of animals • 1800 • LISTER (1840) Carbolic Acid • SEMMELWEIS (1840) Child Birth Fever • PASTEUR (1857) Vaccines • KOCH (1900) Disease Tranmission

  17. Scientific advances which depended on use of animals • 1800 • LISTER (1840) Carbolic Acid • SEMMELWEIS (1840) Child Birth Fever • PASTEUR (1857) Vaccines • KOCH (1900) • Disease • Tranmission

  18. Scientific advances which depended on use of animals • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin • 1920 INSULIN • 1944 Heart Surgery • Helen Taussig • 1955 Polio Vaccines • 1961 Thalidomide

  19. Scientific advances which depended on use of animals • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin • 1920 INSULIN • 1944 Heart Surgery • Helen Taussig • 1955 Polio Vaccines • 1961 Thalidomide

  20. Scientific advances which depended on use of animals • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin • 1920 INSULIN • 1944 Heart Surgery • Helen Taussig 1963 • 1955 Polio Vaccines • 1961 Thalidomide

  21. Scientific advances which depended on use of animals • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin • 1920 INSULIN • 1944 Heart Surgery • Helen Taussig • 1955 Polio Vaccines • 1961 Thalidomide

  22. Scientific advances which depended on use of animals • 1890 vonBehring Diptheria Vaccine & Tetnus antitoxin • 1920 INSULIN • 1944 Heart Surgery • Helen Taussig • 1955 Polio Vaccines • 1961 Thalidomide

  23. Scientific advances which depended on use of animals • 1964 First Monkey to Human Heart Transplant Norman Shumway CA • 1967 First Human to Human Heart Transplant Christiaan Bernard • 1970’s Cimetidine • Cyclosporin • Monoclonal antibodies • 1990 DNA probes Transgenic animals

  24. Scientific advances which depended on use of animals • 1964 First Monkey to Human Heart Transplant Norman Shumway CA • 1967 First Human to Human Heart Transplant Christiaan Barnard • 1970’s Cimetidine • Cyclosporin • Monoclonal antibodies • 1990 DNA probes • Transgenic animals

  25. Scientific advances which depended on use of animals • 1970’s Cimetidine • Cyclosporin • Monoclonal antibodies • 1990 DNA probes • Transgenic animals

  26. Scientific advances which depended on use of animals • Transgenic • animals

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