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Summary of Session I

Tandem Mass Spectrometry in Newborn Screening. Summary of Session I. Bill Becker, DO MPH Ohio Department of Health. Getting Started. Planning – space, equipment, training Importance of a clinical perspective State’s Advisory Committee/Council Educational materials Parents & providers

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Summary of Session I

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  1. Tandem Mass Spectrometry in Newborn Screening Summary of Session I Bill Becker, DO MPH Ohio Department of Health

  2. Getting Started • Planning – space, equipment, training • Importance of a clinical perspective • State’s Advisory Committee/Council • Educational materials • Parents & providers • Good Communication

  3. Instrument Performance • Training, Training, & More Training • Understand instrument performance • “soup to nuts” • Optimize variables • Understand the things that impact “run time” • Internal Standards

  4. Method Validation • Linearity • Precision – inter and intra-assay • Accuracy/Precision • Target CV’s suggested

  5. Other Considerations • Interferences & Sources of Contamination • Establishing Analyte Cutoffs • Quality Control & Quality Assurance Plans • Document, Document, Document

  6. Routine Operations • Maintenance • Tuning Solution • Reagent & I.S. Preparation • Preparation of Samples & Controls • Analysis & Data Handling

  7. Summary • Plan Ahead • Train & Educate • Rigorous Method Validation • Establish a Quality Assurance Plan • Communicate Well with Community

  8. Tandem Mass Spectrometry in Newborn Screening - Resources • CDC NBS QA Program • Association of Public Health Laboratories • National Newborn Screening & Genetics Resource Center • Training – Laboratory & Follow up • Listserv’s – general NBS, also MS Users Group • Dr Brad Therrell, 512-454-6419, therrell@uthscsa.edu

  9. Questions?

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