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From Noah’s Arkive

From Noah’s Arkive. From Noah’s Arkive. From Getty, 1975 . From Smith,3 rd ed. Galt trephine. A. Woolums, LAMS 5301. From Noah’s Arkive. From Noah’s Arkive. tracheostomy tube. A. Woolums, LAMS 5301. From Noah’s Arkive. From Noah’s Arkive. From Noah’s Arkive. From Noah’s Arkive.

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From Noah’s Arkive

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  1. From Noah’s Arkive

  2. From Noah’s Arkive

  3. From Getty, 1975

  4. From Smith,3rd ed. Galt trephine A. Woolums, LAMS 5301

  5. From Noah’s Arkive

  6. From Noah’s Arkive

  7. tracheostomy tube A. Woolums, LAMS 5301

  8. From Noah’s Arkive

  9. From Noah’s Arkive

  10. From Noah’s Arkive

  11. From Noah’s Arkive

  12. M. haemolytica leukotoxin LPS CD18/CD11a (LFA 1) proteases elastases reactive O2 CD 14 tissue necrosis IL-8 Fibrinous, necrotizing bronchopneumonia TNF-a, IL-1b edema, hemorrhage, thrombosis endothelial cell activation A. Woolums, LAMS 5301

  13. Drugs appropriate for M haemolytica • tetracycline • LA 200 (3-day), Tetradure (7 day) • spectinomycin • ceftiofur • Naxcel, Excenel, Excede (7 day) • tilmicosin • Micotil (3 day) • florfenicol • Nuflor (2 or 4 day) • enrofloxacin or danofloxacin • Baytril or A180 (2 day) • Tulathromycin • Draxxin (7-14 days) A. Woolums, LAMS 5301

  14. Some M. haemolytica vaccines • Once PMH®(Bayer) • avirulent live • One Shot®(Pfizer) • bacterin-toxoid (leukoktoxin, capsular, and cell-associated antigens) • Pulmo-Guard™ PH-1 (Bio-Ceutic) • bacterin-toxoid (leukotoxin and cell associated antigens) • Presponse® SQ (Fort Dodge) • adjuvanted toxoid (leukotoxin) A. Woolums, LAMS 5301

  15. From Noah’s Arkive

  16. From Noah’s Arkive

  17. Some P. multocida vaccines • Once PMH®(Bayer) • avirulent live P. multocida (with M. haemolytica) • Pulmo-Guard™ PH-M (Bio-Ceutic) • contains cell associated antigens of P. multocida (with M. haemolytica leukotoxin and cell-associated ags) • Presponse® HM (Fort Dodge) • P. multocida bacterial “extract”(with M. haemolytica leukotoxin) • Bar-4 (Bio-Ceutic) • formalin-inactivated P. multocida with adjuvant (with inactivated BHV-1, PI3, and M. haemolytica) A. Woolums, LAMS 5301

  18. From Noah’s Arkive

  19. From Noah’s Arkive

  20. From Noah’s Arkive

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  22. From Noah’s Arkive

  23. From Noah’s Arkive

  24. From Noah’s Arkive

  25. From Noah’s Arkive

  26. Drugs appropriate for M bovis • tetracycline • oxytetracycline (parenteral) • chlortetracycline (in feed; remember extra label restrictions) • spectinomycin • florfenicol • enrofloxacin or danofloxacin (extra-label?) • tulathromycin (specifically labelled)

  27. From Noah’s Arkive

  28. From Noah’s Arkive

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