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Avrio Medical . Small Heart EKG Arrhythmia Research Tool Cardiac Mapping - Microvolt Signal Acquisition Seddrak Luu George Kwei Jeff Chang Joe Ma Eric Chow Kenny Pak. Overview. Business aspect Marketing Cost Technical aspect Hardware Software. Arrhythmia.
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Avrio Medical Small Heart EKG Arrhythmia Research Tool Cardiac Mapping - Microvolt Signal Acquisition Seddrak Luu George Kwei Jeff Chang Joe Ma Eric Chow Kenny Pak
Overview • Business aspect • Marketing • Cost • Technical aspect • Hardware • Software
Arrhythmia • Junctional Ectopic Tachycardia • Disorders of the regular rhythmic beating of the heart • Occur in children after open heart surgery • 1 in 10 infant goes into arrhythmia after open heart surgery • Can be lethal
The Big Picture • understanding the patho-physiology of JET
Goal • a Small Heart EKG System to help understand the Arrhythmia • Focus on helping those in need rather than actual profit
Executive Team Seddrak Luu Jeff Chang Joe Ma George Kwei Eric Chow Kenny Pak
BCRI Correspondence • Dr. Glen Tibbits • Director Cardiovascular Sciences Professor of Kinesiology, Simon Fraser University (SFU) • Helen Sheng (Graduate Student, MD) • Eric Lin (Graduate Student)
Other Sources of Information • Margaret Evans, • Advanced Measurements • Andrew Pruszynski • Wireless Medical Devices, TA • SFU Faculty • School of Kinesiology/Engineering
Structure of the Project • Signal Retrieval Stage • Signal Transmission • Signal Processing • Signal Analysis
Avrio Core Business 1. Small Heart EKG - commercial introductions expected in a few years. Business Based on the Product 2. Platinum Electrode Tips 3. Customize Circuitry to suit the need 4. Customize the Labview Interface
Business • Current Client • Dr. Glen Tibbits of BC Research Institute of Chilrdren’s and Women’s
Statistics • In British Columbia, ~40,000 babies were born* • 600 babies are born with congenital heart disease • Of that about 200 will require open heart surgery • 1 in 10 will go into Arrhythmia *From Statistics Canada
Market Strategy (Short Term) • Short Term • Research Based Institute • Children Hospitals and Children Research Institute
Marketing Strategy (Long Term) • Long Term • Organization that supports the developing countries • United Nation • Unicef • Engineers / Doctors Without Borders • Aim for developing countries trying to do heart research with minimal budget
Improvements • Electrode Grid with more electrode • Increase number of electrodes per grid • Tailor specific small EKG and interface for specific customerdepending on the type of heart
Prototype • Total Cost: $ 751.16 • Research: $ 134.01 • Electrodes, Gel, Gel Pad • Material: $ 575.29 • Wires, Breadboard, Necessary Components • Shipping: $ 41.86
Product Price for Small Heart EKG Component Price • 24 x AD620 $6.00 • 4 x TL072 $1.00 • Capacitors / Resistors $15.00 • Wiring (Copper) $1.00 • Wiring (Platinum) $4.00 • Breadboard $20.00 • Batteries $3.00 • Miscellaneous and Casing $5.00 • NET PRODUCT PRICE $58.80 • Labour (6 hours) $72.00 • Labview Interface $39.00 • TOTAL $169.80
Heart Setup • Preparation of the heart • Biology of the heart
Video of the Heart • Here we present some excerpts of the in lab trials of our designed device.
Electrodes • Initial Design Concepts/Problems • A grid system • Compact • Isolated • A flexible wrap
Electrodes • Final Design • Coiled platinum electrode tips • Grounded Tin Foil Shielding • Braided wires with metallic shielding
Challenges Incurred • Electrode Tip • Size & Weight • Crosstalk • Interference • Positioning Electrodes
Challenge: Electrode Tip • Type of material necessary • Amount of surface contact • Physical spacing of electrodes • # of possible electrode tips
Challenge: Size & Weight • 2-5 grams • 1.5x1.5x1.5 cm dimensions • This is a very small testing area. • We were only able to use ¼ of the heart surface for relevant probing data.
Challenge: Crosstalk • Crosstalk aka additive/subtractive signals • This is caused by close proximity of the electrode • Solution: • Only preventative measures such as spacing of electrode tips could be used • Future versions of systems will have software solution to this problem
Challenge: Interference • Outside electrical sources such as power lines and light bulbs • Most common is the 60Hz noise • Seen from the building power lines • Solution: • Cross braiding of the electrode leads • A metal shielding from artificial light
Challenge: Positioning Electrodes • Initially we hand probed the heart as an initial step. • This was sufficient for testing but not very accurate. • Solution: • A mounting device for the electrode bundle • Needed to carefully hand manipulate the electrode tips so that they made no contact with each other.
Signal Conditioning Circuitry • Provide Gain • Heart signal is low-milli to high-micro Volt range • Filtering • Get rid of noise from environment and other lab equipment
Circuit Design • AD620 has high Input Impedance • Low power, low cost • -40dB Filter • Filtering Cutoff Frequencies at 15Hz
A/D • National Instrument BNC-2090 • National Instrument AT-MIO-16E-10
Labview • Testing • Signal Acquisition • Signal Conditioning • Signal Analysis
Labview: Simulating the Heart • Generate small heart signals • Generate background noise
Labview: Acquiring Data • Write data to file • Filter acquired data • Show frequency domain
Ischemia • Inverted T-wave
Bundle Branch Block • Wide QRS Complex • Caused by activation of the left ventricle prior to activation of the right ventricle
Atrial Flutter • Wide QRS complex • Inverted T-wave: Ischemia • Short PR-PR intervals • “saw tooth” pattern
Bundle Branch Block • Wide QRS Complex • Caused by activation of the left ventricle prior to activation of the right ventricle
Ventricular Tachycardia • AV dissociation, no relationship between P-wave and QRS complex • Wide QRS
Final Comments • What we learned from this: • Biological Structure of the heart • Biological Signal Processing • Signal Acquisitio • Hardware Filtering • Software Analysis
Signs of Success • We learned a lot about biology,software and hardware. • We were able to obtain usable small signals that could be analyzed. • Finally • We started with 6 group members and we still have 6 group members. YAY!
Contacts • Company Website: www.sfu.ca/~sluu/avrio • Company Email: • ensc340-wireless@sfu.ca
Questions? • Comments