Diabetes Fundamentals Series

1. Diabetes Fundamentals Series Beverly Dyck Thomassian, RN, MPH, BC-ADM, CDE President, Diabetes Education Services www.DiabetesEd.net2019

2. Welcome to Diabetes Fundamentals • Series of 6 courses designed to provide you with the building blocks of diabetes care • Within 24 hours of the live broadcast, we will have the recorded version posted on our Diabetes Education University (DEU). • Updated PowerPoint handouts will have 2019 in the Description • Earn CE certificate by taking post test and survey on our DEU Site. • Please contact Anne with any questions! Anne@diabetesed.net

3. Course Objectives Discuss factors contributing to increased prevalence of diabetes Describe pathophysiological defects associated with the development of diabetes mellitus. Differentiate the different types: prediabetes, Type 1, Type 2 and GDM Discuss new language guidelines Describe the impact of insulin resistance

4. Foundations of Care • Education • Nutrition • Monitoring • Physical Activity • Psychosocial Care • Medications • Reducing Risk • Getting to Best Possible Health

5. Improving Care & Promoting Health • Start with patient centered communication. • Incorporate pt preferences, literacy, life experiences • Treatment decisions timely, based on evidence and tailored to individual pt. • Align care with Chronic Care Model to ensure proactive practice and informed, activated patient. • Assess social context, including food insecurity, housing stability, financial barriers and apply to treatment decisions.

6. CDC Announces 35% of Americans will have Diabetes by 2050 Boyle, Thompson, Barker, Williamson 2010, Oct 22:8(1)29 www.pophealthmetrics.com

7. Diabetes in America 2019 • 30.3 million or > 9.4% • 24% don’t know they have it • 34 % of US adults have pre diabetes (84 mil)

8. Age-adjusted Diabetes Prevalence 20 yrs or older, by race/ethnicity— U.S. 2013-2015

9. Obesity and Economics in America • 68% overweight or obese • 34% BMI 30 +, 34% BMI 25-29 • 1/3 of all overwt people don’t get diabetes • We burn 100 cals less a day at work • Overall, food costs ~ 10-15% of income • Calorie Intake is on the rise

10. Now, let’s get to the Nitty Gritty

12. Poll Question 1 • In the fasting state, hyperglycemia is directly related to: • Increased hepatic glucose production • Defective insulin stimulation of target tissue glucose disposal • Decreased adipocyte lipolysis • Loss of pancreatic alpha-cell function

13. Hormone Glucagon (pancreas) Stress hormones (kidney) Epinephrine (kidney) Insulin (pancreas) Amylin (pancreas) Gut hormones - incretins (GLP-1) released by L cells of intestinal mucosa, beta cell has receptors) Hormones Effect on Glucose Effect      

14. Polyuria Polydipsia Polyphasia Weight loss Fatigue Skin and other infections Blurry vision Glycosuria, H2O losses Dehydration Fuel Depletion Loss of body tissue, H2O Poor energy utilization Hyperglycemia increases incidence of infection Osmotic changes Signs of Diabetes

15. Poll Question 2 • Pre-diabetes is defined as a glucose of: • Fasting BG of 100-125 mg/dl • Any BG above 99 mg/dl • Fasting BG 126 -200 mg/dl • Fasting BG of 140 mg/dl or more

16. Natural History of Diabetes NO Yes! Development of type 2 diabetes happens over years or decades

17. Poll Question 3 • Diabetes is defined as a random glucose of • 126-199 mg/dl • 200 mg/dl or greater • 140-199 mg/dl • 140 mg/dl or greater

18. Diagnostic Criteria • All test should be repeated in the absence of unequivocal hyperglycemia • If test abnormal, repeat same test to confirm diagnosis on a different day • If one test normal, the other abnormal, repeat the abnormal test to determine status • Medicare still using fasting as criteria for reimbursement for education

19. A1c Test – To diagnose & eval • Measures glycation of RBC’s over 2-3 months • Weighted mean (50% preceding month) • Each 1% ~ 29mg/dl • Accuracy: affected by some anemias, hemoglobinopathies • A measurement of glucose in fasting and postprandial states • African Americans may have false lows

21. Poll Question 4 • Each percentage of A1c = how many mg/dl of blood glucose? • 33 • 27 • 17 • 29

22. A1c and Estimated Avg Glucose (eAG) A1c (%) eAG 5 97 6 126 7 154 8 183 9 212 10 240 11 269 12 298 eAG = 28.7 x A1c-46.7 ~ 29 pts per 1% Translating the A1c Assay Into Estimated Average Glucose Values – ADAG Study Diabetes Care: 31, #8, August 2008 Order teaching tool kit free at diabetes.org

23. What Kind of Diabetes? • AJ, a 12 year old female admitted to the ICU with a blood glucose of 476 mg/dl and a pH of 7.1. • What further questions and or testing is needed to determine if patient has type 1 or type 2 diabetes?

24. Type 1 Diabetes

25. What Does Type 1 Look Like? Mary Tyler Moore Justice Sonia Sotomayor Bret Michaels Nick Jonas

26. Type 1 Rates Increasing Globally • 23% rise in type 1 diabetes incidence from 2001-2009 • Why? • Autoimmune disease rates increasing over all • Changes in environmental exposure and gut bacteria? • Hygiene hypothesis • Obesity?

27. General Pop 0.3% Sibling 4% Mother 2-3% Father 6-8% Rate doubling every 20 yrs Many trials underway to detect and prevent (Trial Net) Incidence of Type 1 in Youth

28. Type 1 – 10% of all DiabetesGenetics and Risk Factors • Auto-immune pancreatic beta cells destruction • Most commonly expressed at age 10-14 • Insulin sensitive (require 0.5 - 1.0 units/kg/day) • Combo of genes and environment: • Autoimmunity tends to run in families • Higher rates in non breastfed infants • Viral triggers: congenital rubella, coxsackie virus B, cytomegalovirus, adenovirus and mumps.

29. Type 1 Positive antibodies GAD ICA IAA and others Younger people develop quickly Older people take longer to develop Body wt and presentation How do we know someone has Type 1 vs Type 2?

30. Autoantibodies Assoc w/ Type 1 Panel of autoantibodies – • GAD65 - Glutamic acid decarboxylase – • ICA - Islet Cell Cytoplasmic Autoantibodies • IAA - Insulin Autoantibodies

31. Poll Question 5 What factors would make you suspect type 1 diabetes? a. Pt has a history of celiac disease b. Pt presents with low HDL cholesterol c. Friend tells you she has been eating "tons of sweets“ d. Pt is slightly overweight

32. Type 1 Diabetes Associated with other immune conditions • Celiac disease (gluten intolerance) • Thyroid disease • Addison’s Disease • Rheumatoid arthritis • Other

33. Type 1 Summary • Autoimmune pancreatic destruction • Need insulin replacement therapy • Often first present in DKA • At risk for other autoimmune diseases • Eval coping strategies

34. Patti Labelle "divabetic” “I have diabetes, it doesn’t have me”

35. Path to Type 2 Diabetes

36. BMI – Visual Image

38. Insulin Resistance is the Seed

39. Factors Associated with Insulin Resistance • Abdominal obesity • Sedentary lifestyle • Genetics / Ethnicity • Gestational Diabetes • Polycystic ovary syndrome • AcanthosisNigricans • Obstructive Sleep Apnea • Cancer American College of Endocrinology, 2001

40. AcanthosisNigricans

41. Acanthosis Nigricans (AN) • Signals high insulin levels in bloodstream • Patches of darkened skin over parts of body that bend or rub against each other • Neck, underarm, waistline, groin, knuckles, elbows, toes • Skin tags on neck and darkened areas around eyes, nose and cheeks. • No cure, lesions regress with treatment of insulin resistance

42. Pre Diabetes & Type 2- Screening Guidelines(ADA Clinical Practice Guidelines) • Start screening all people at age 45 or anyone who is overweight (BMI  25, Asians BMI  23 ) with one or > additional risk factor: • First-degree relative w/ diabetes • Member of a high-risk ethnic population • Habitual physical inactivity • PreDiabetes • History of heart disease

43. Diabetes 2 - Who is at Risk?(ADA Clinical Practice Guidelines) Risk factors cont’d • HTN - BP > 140/90 • HDL < 35 or triglycerides > 250 • history of Gestational Diabetes Mellitus • Polycystic ovary syndrome (PCOS) • Other conditions assoc w/ insulin resistance: • Severe obesity, acanthosisnigricans (AN)

44. Poll Question 7 • Frequent skin and yeast infections in people with diabetes are: • A sign of poor hygiene • Due to poor diet • A sign of ongoing hyperglycemia • A result of high sugar intake

45. Glycosuria, H2O losses Dehydration Fuel Depletion Loss of body tissue, H2O Poor energy utilization Hyperglycemia increases incidence of infection Osmotic changes Signs of Diabetes • Polyuria • Polydipsia • Polyphasia • Weight loss • Fatigue • Skin and other infections • Blurry vision

46. What is Type 2 Diabetes? • Complex metabolic disorder …. (Insulin resistance and deficiency) with social, behavioral and environmental risk factors unmasking the effects of genetic susceptibility. New Diagnosis? Call 800 – DIABETES to request “Getting Started Kit” www.Diabetes.org

47. Natural Progression of Type 2 Diabetes Postprandial glucose Plasma Glucose Fasting glucose 126 mg/dL Insulin resistance Relative -CellFunction Insulin secretion -20 -10 0 10 20 30 Years of Diabetes After diagnosis Prior to diagnosis Adapted from Bergenstal et al. 2000; International Diabetes Center.

48. Ominous Octet Decreasedsatiation neuro- transmission Decreased amylin, -cell secretion 80% loss at dx Increased renal glucose reabsorption Decreased Gut hormones Increased glucagon secretion G I I G G I G G Increased lipolysis I G I G I G I G I Increase glucose production G G Decreased glucose uptake

49. Life Study – Mrs. Jones Mrs. Jones is 62 years old, with a BMI of 36 and complains of feeling tired and urinating several times a night. She has an urinary tract infection. Her A1c is 8.3%, glucose 237. She is hypertensive with a history of gestational diabetes. No ketones in urine. • What are her risk factors and signs of diabetes? • You find a few moments to teach and she asks you some questions.

50. What negative words / phrases have you heard regarding people with diabetes? • Cheat(er) • No will power • Diabetic • Lazy, weak • Non-compliant • Train wreck • Frequent Flyer • Non-adherent • Refuses to check blood sugar • Forgot log book again • Refuses to take their meds as directed • Eats junk food • Loves sugar • They brought it on themselves