T cell Maturation, Activation & Differentation

1. T cell Maturation, Activation & Differentation Hugh B. Fackrell

2. T cell Maturation, Activation & Differentation • Assigned Reading • Content Outline • Performance Ojectives • Key terms • Key Concepts • Short Answer Questions

3. Assigned Reading • Chapter: 12 pp 285-310 • Janis Kuby’s Immunology 3rd Ed

4. T Cell Maturation T helper Cell Activation T Cell Differentiation Peripheral gamma delta T cells Content Outline

5. Pre T cell receptor T cell development pathways Thymic Selection of T cells positive selection negative selection T helper Cell Activation TCR coupled signaling pathways Co-stimulatory signal Antagonists & Agonists Clonal Expansion Clonal Anergy Superantigens T Cell Maturation

6. T Cell Differentiation • Effector & memory cells • Co-stimulatory differences

7. Peripherial T cells • Distribution of cells • Ligands recognized • Functions

8. Performance Objectives

9. Key Terms • accessory molecules, antigen processing, associatve recogonition model, • independent recognition model, cell adhesion molecules, • subtractive hybrization

10. Key Concepts • Outline antigen processing and presentation to TCR • Describe the molecular pathways for T cell activation • Describe positive and negative selection • Discuss the role of accessory molecules in T cell antigen recognition

11. Short Answer Questions

12. T cell proliferation and differentiation lead to important immunological functions. What are they? • Briefly discuss the molecular events, collected called T-Cell activation, that lead to biologic function. • What is the importance of diacylglycerol and IP3 in T-cell activation? • What transcription factors are involved in T cell activation?

13. DONE!!!