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First, what do we know about NIH support for obesity science?

“How Can Providers Address the Lack of R01 Studies?” Robert H. Eckel, M.D. Professor of Medicine Professor of Physiology and Biophysics University of Colorado Denver. First, what do we know about NIH support for obesity science?. NIH Research Obesity Task Force.

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First, what do we know about NIH support for obesity science?

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  1. “How Can Providers Address the Lack of R01 Studies?”Robert H. Eckel, M.D.Professor of MedicineProfessor of Physiology and BiophysicsUniversity of Colorado Denver

  2. First, what do we know about NIH support for obesity science?

  3. NIH Research Obesity Task Force • Established by NIH Director Dr. Elias Zerhouni in April 2003. • A new effort to accelerate progress in obesity research across the NIH. • Co-Chaired • Dr. Griffin P. Rogers, Director NIDDK • Dr. Elizabeth G. Nabel, Director NHLBI

  4. Strategic Plan for NIH Obesity Research • Prevention and treatment of obesity through lifestyle intervention. • Prevention and treatment of obesity pharmacologic, surgical, or other medical approaches. • Breaking the link between obesity and its associated health conditions. • Cross-cutting topics including health disparities, technology, fostering interdisciplinary teams, investigator training, translational research and educational/outreach efforts.

  5. NIH Components Represented on the Obesity Task Force

  6. Presently, the NIH cannot accurately provide information on the # of R01s that address obesity science.This will change once the categorization has been modified – see http://report.nih.gov/rcdc/

  7. NIH Obesity-Related Funding

  8. NIH Obesity Research Funding Opportunities • Obesity Research Solicitations Currently Accepting Applications • RFAs • RFA-DK-08-009: Neuroimaging in Obesity Research (R01) RFA-HL-08-013: Translating Basic Behavioral and Social Science Discoveries into Interventions to Reduce Obesity: Centers for Behavioral Intervention Development (U01)RFA-HD-08-023: Innovative Computational and Statistical Methodologies for the Design and Analysis of Multilevel Studies on Childhood Obesity (R01)RFA-DK-08-505: Limited Competition: Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) (U01) • PAs • n = 46 • Ongoing Clinical Trials (Federal and Private) - ClinicalTrials.gov • n = 1328

  9. A major question is – do we know that weight loss prolongs life?

  10. And the only data come from one study of bariatric surgery!

  11. Effects of Bariatric Surgery on Weight in Swedish Obese Subjects Sjostrom LA et al NEJM 357:471, 2007

  12. Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects Sjostrom LA et al NEJM 357:471, 2007

  13. Will Look AHEAD Answer All the Questions? • Primary Objective: Assess long-term (11.5 yr) effects of an intensive weight loss program over 4 years in overweight and obese subjects with type 2 diabetes. • n ~ 5000 men and women • age: 45-74 yr • BMI > 25 kg/m2 • Primary outcome – time to a major CVD event • Secondary outcomes – many including all cause mortality Controlled Clin Trials 24:610, 2003

  14. Look AHEAD Trial: Improvement in Metabolic Syndrome Components at 1 Year Look AHEAD Research Group. Diabetes Care 30:1374, 2007

  15. Obesity Research Support Related Questions • What kind of priority should NIH-supported obesity research funding receive? • How much money is needed? • If sufficient funding is provided, how much impact will result? • What is the role of industry?

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