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Beta-Globin gene Activity

Image from: http://learn.genetics.utah.edu/content/disorders/whataregd/sicklecell/. Beta-Globin gene Activity. From a kit by 3 D Molecular Designs. Image from: http://en.wikipedia.org/wiki/Hemoglobin. http://gassama.myweb.uga.edu/hemoglobinmolecule.gif. Amino acid sequence.

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Beta-Globin gene Activity

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  1. Image from: http://learn.genetics.utah.edu/content/disorders/whataregd/sicklecell/ Beta-Globin gene Activity From a kit by 3 D Molecular Designs Image from: http://en.wikipedia.org/wiki/Hemoglobin

  2. http://gassama.myweb.uga.edu/hemoglobinmolecule.gif

  3. Amino acid sequence aa Code amino acid mRNA codes DNA Codes M= ________ ________ ______ V= ________ ________ ______ TAC AUG Methionine CAACAGCATCAC GUUGUCGUAGUG valine

  4. Sickle Cell disease (anemia) http://learn.genetics.utah.edu/content/disorders/whataregd/sicklecell/images/sicklecell.jpg

  5. http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/Gifs/HBBmutseq_2.gifhttp://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/Gifs/HBBmutseq_2.gif

  6. 5 kinds of hemoglobin subunits • Alpha (σ) • Beta (β) • Gamma (ϒ) • Delta (δ) • Epsilon (ϵ)

  7. Adult hemoglobin σ2β2 - 2% of adult hemoglobin = σ2δ2 Embryonic hemoglobin σ2ϵ2 Fetal Hemoglobin σ2ϒ2 • Greater affinity for oxygen than adult hemoglobin • last seven months of development in uterus • in the newborn until roughly 6 months old Sickle cell hemoglobin σ2β2 • Mutation in β chain

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