1 / 11

DCEG Studies and Biospecimen Management

DCEG Studies and Biospecimen Management. Jim Vaught, Ph.D. Special Assistant for Biological Resources Division of Cancer Epidemiology & Genetics. Division of Cancer Epidemiology & Genetics (DCEG).

levi
Download Presentation

DCEG Studies and Biospecimen Management

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. DCEG Studies andBiospecimen Management Jim Vaught, Ph.D. Special Assistant for Biological Resources Division of Cancer Epidemiology & Genetics

  2. Division of Cancer Epidemiology & Genetics (DCEG) “..a national program for population-based studies to identify environmental and genetic determinants of cancer.” • Biostatistics Branch • Environmental Epidemiology Branch • Genetic Epidemiology Branch • Nutritional Epidemiology Branch • Occupational Epidemiology Branch • Radiation Epidemiology Branch • Viral Epidemiology Branch

  3. DCEG Biorepository Program • ~7,000,000 biospecimens in inventory • Over 450 studies with specimen collections – directed by about 60 DCEG PIs • Biorepository support contracts: collection, bioprocessing, storage, shipping • Bioprocessing: blood processing, cryopreservation, aliquoting, DNA extraction, biomarker assays • Emphasis on quality control & growth management

  4. DCEG Contract Biorepository

  5. DCEG Biorepositories

  6. Examples from among 80+ specimen types in DCEG biorepositories

  7. DCEG Biorepositories – more specimen types

  8. Specimens for Molecular Epidemiology Studies • Micronutrients – vitamins, carotenoids, fats • Genotyping, DNA sequencing • Mutation analyses • Virus detection - HPV, HHV, HIV • Pesticides & PCBs • Polycyclic hydrocarbons • Water contaminants • Endogenous hormone assays • Insulin-like growth factors

  9. Genotyping for DCEG studies • DNA extraction - ~80,000 specimens during 2002-2003 at contract labs • Genotyping - ~35,000 samples from about 25 studies, total of ~1,000,000 assays requested at CGF • Additional DCEG studies approved for genotyping either at CGF or by commercial vendor

More Related