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Particle Size and Shape in Pharmaceutical Applications

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Particle Size and Shape in Pharmaceutical Applications

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    1. www.ParticleSize.com 1 Particle Size and Shape in Pharmaceutical Applications Michael Levin, Ph. D., President Sean Murphy, Vice-President Metropolitan Computing Corporation

    2. www.ParticleSize.com 2 Definitions of terms used in size analysis Mean Diameters D10, D50, D90 Equivalent Diameters

    3. www.ParticleSize.com 3 Definitions of terms used in size analysis: Mean Diameters

    4. www.ParticleSize.com 4 Definitions of terms used in size analysis: Mean Diameters

    5. www.ParticleSize.com 5 Definitions of terms used in size analysis: Statistical Distributions

    6. www.ParticleSize.com 6 Definitions of terms used in size analysis: Statistical Distribution Parameters

    7. www.ParticleSize.com 7 Definitions of terms used in size analysis: Equivalent Diameters

    8. www.ParticleSize.com 8 Definitions of terms used in shape analysis Equivalent Diameter Feret Diameter Aspect Ratio Shape Factor

    9. www.ParticleSize.com 9 Definitions of terms used in shape analysis: Equivalent Diameter

    10. www.ParticleSize.com 10 Definitions of terms used in shape analysis: Feret Diameter

    11. www.ParticleSize.com 11 Definitions of terms used in shape analysis: Aspect Ratio

    12. www.ParticleSize.com 12 Definitions of terms used in shape analysis: Shape Factor

    13. www.ParticleSize.com 13 Accepted Standards and Techniques

    14. www.ParticleSize.com 14 Accuracy vs. Precision

    15. www.ParticleSize.com 15 How to Choose a Particle Sizer Sieving Sedimentation Laser Diffraction Laser Obscuration Microscopy (Image Analysis) Electrozone Sensing Dynamic Light Scattering Time-of-Flight Mass Spectrometry Focused-Beam Reflectance Measurement

    16. www.ParticleSize.com 16 How to Choose a Particle Sizer: Sieving

    17. www.ParticleSize.com 17 How to Choose a Particle Sizer: Sedimentation

    18. www.ParticleSize.com 18 How to Choose a Particle Sizer: Laser Diffraction

    19. www.ParticleSize.com 19 How to Choose a Particle Sizer: Laser Obscuration

    20. www.ParticleSize.com 20 How to Choose a Particle Sizer: Microscopy (Image Analysis)

    21. www.ParticleSize.com 21 How to Choose a Particle Sizer: Electrical Zone Sensing

    22. www.ParticleSize.com 22 How to Choose a Particle Sizer: Dynamic Light Scattering

    23. www.ParticleSize.com 23 How to Choose a Particle Sizer: Time of Flight Mass Spectrometry

    24. www.ParticleSize.com 24 How to Choose a Particle Sizer: Focused-Beam Reflectance Measurement (FBRM)

    25. www.ParticleSize.com 25 Pharmaceutical Applications: AAPS Workshop

    26. www.ParticleSize.com 26 Pharmaceutical Applications: Is Accuracy Important?

    27. www.ParticleSize.com 27 Pharmaceutical Applications: Wet Granulation

    28. www.ParticleSize.com 28 Pharmaceutical Applications: Compaction

    29. www.ParticleSize.com 29 Pharmaceutical Applications: The Shape Challenge

    30. www.ParticleSize.com 30 Pharmaceutical Applications: Regulatory Concerns

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