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CBV t = 3.76 ml/100g

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CBV t = 3.76 ml/100g

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  1. Fig. S1. Time courses of CBVa and CBVt (upper row), and CBVv (lower row) from upper (A), middle (B) and lower (C) cortical ROIs (each ROI shown in inserted figure). CBVt and CBVv were obtained at three different baseline conditions, 3.76ml/100g (blue circles), and 4.5 (purple triangles) and 5.0 ml/ 100 g (green squares). Colored solid lines: best fitted curves; black bars: 40-s stimulation period.

  2. CBVt = 3.76 ml/100g A mean CBVv/ mean CBVt (%) CBVt = 4.5 ml/100g B mean CBVv/ mean CBVt (%) CBVt = 5.0 ml/100g C Fig. S2. Stimulus-duration-dependent contribution of venous CBV to total CBV change. Ratios were calculated with three baseline CBVtof 3.76(A), 4.5 (B) and 5.0 ml/ 100 g (C)from upper (blue), middle (pink) and lower (purple) cortical ROIs (each ROI shown in Fig. S1). mean CBVv/ mean CBVt (%) 6 – 10 6 – 15 6 – 20 6 – 25 6 – 30 6 – 35 6 – 40 s Duration after stimulation onset (s)

  3. 1.0 1.2 1.4 1.6 1.8 0 0.2 0.4 0.6 0.8 A CBVv 0 0.3 ml/100g B C CBVt (ml/ 100g) CBVv (ml/ 100g) Distance from cortical surface (mm) Distance from cortical surface (mm) Fig. S3. Time-dependent CBVv maps of one animal shown in Fig. 5 (A), and average cortical profiles of CBVt (B) and CBVv (C), obtained with the assumption of baseline CBVt = 5 ml/100 g.

  4. R2*artery = 150 R2*artery = 130 R2*artery = 110 R2*artery = 90 R2*artery = 70 R2*artery = 50 Intercept (%) R2*artery (s-1) Fig. S4. Simulation of arterial blood volume change depend on R2*of arterial blood (R2*artery ) and its change during stimulation (R2*artery). Simulations were performed with va = 1%; R2*,tissue = 50 s-1; TE = 20 ms; va = 0.2%; and various R2*,artery and its changes. When R2*,artery > R2*,tissue, then va obtained with our simplified assumptions is overestimated. When R2*,artery increases, a is underestimated.

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